Abstract
Background: Diabetes mellitus (DM) is a group of metabolic disease characterized by increase blood glucose level resulting from defects in insulin secretion, insulin action, or both.
Methods: This is a cross sectional case control study.100 patients of type 2 diabetes mellitus and 100 age and sex matched healthy controls were taken. Lipid profile were done in cases and controls using appropriate tests.
Results: Mean age in diabetic patients was 48.23± 9.24 years and control patients was 47.28± 9.84 years and age range was 20-70 years. The FBS levels in all the diabetics were significant (p<0.05) as compare to control. There was significant difference in mean HDL, Triglycerides level in diabetic and control patients (p<0.05). There was no significant difference in LDL, Cholesterol level in Diabetic and control patients (p>0.05).
Conclusion: We conclude that there is a high prevalence of elevated lipid and lipoprotein levels among the diabetic patients showing that they are more prone to these abnormalities,
Keywords: Diabetes Mellitus -2, Cholesterol, Lipid Profile.
References
- American Diabetes Association. Diagnosis and classification of diabetes Mellitus. Diabetes Care.2005;28(1):537-42.
- Shera, A.S., F. Jawad and A. Maqsood, A. Prevalence of diabetes in Pakistan. Diabetes Res.Clini. Pract.2007;76(2):219-22.
- Roberto, T., A.R. Dodesini, Lepore G. Lipid and Renal disease. J. Am. Soc. Nephrol.2006;17: S145-7.
- Devrajani, B.R., S.Z. Shah, A.A. Soomro and T. Devrajani. Type 2 diabetes mellitus: A risk factor for Helicobacter pylori infection: A hospital based case-control study. Int. J. Diabetes Dev. Ctries. 2010;30(1):22-6.
- Mohan V, Deepa M, Deepa R, Shanthirani CS, Farooq S. Secular trends in the prevalence of diabetes and impaired glucose tolerance in urban south India – The Chennai urban rural epidemiology study (CURES-17). Diabetalogia 2006;49: 1175-78.
- Kumar A, Kulshrestha M, TripathiA, Sharma M and Kartikeya. A study of correlation between carotid intima - media thickness and diastolic dysfunction in asymptomatic type 2 Diabetics.IJCMR. 2016;3:1458-1460.
- Bhalla Kapil, Shukla R, Gupta VP et al. Glycosylated proteins and serum lipid profile in complicated and uncomplicated NIDDM patients. Indian J. Clin Biochem.1995;10(2):57-61.
- Krauss RM. Lipids and lipoproteins in patients with type 2 diabetes. Diabetes Care. 2004;27:1496–504.
- Witztum JL, Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest. 1991;88:1785– 92.
- UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352:837–853.
Corresponding Author
Mukesh Gupta
Professor & HOD, Department of General Medicine, Govt. Medical College, Bharatpur, Rajasthan, India
DOI: https://dx.doi.org/10.18535/jmscr/v7i2.59
