Abstract
Background: In India, Breast cancer is the most common cancer in female and hormone receptor status is an important prognostic and therapeutic tool in the management of breast cancer. So this study was done with the aim to evaluate the hormone receptor status in patients with operable breast cancer at a Regional Cancer Centre in Northeast India.
Methodology: This study is a retrospective case series study on 180 cases of operable breast cancer who were registered at Regional Cancer Centre, Regional Institute of Medical Sciences (RIMS), Manipur State after histopathological confirmation during the period from September 2015 to August 2018 and patients were reviewed for age, tumour size and metastatic lymph nodes positivity, histopathology, grading, hormone receptor status, staging and menstrual status.
Results: Overall 180 patients was studied and evaluated for hormone receptor status. 90 cases (50.0%) were both ER-/PR-, 66 cases (36.7%) were both ER+/PR+, 14 cases (7.8%) were ER+ and 10 other cases (5.5%) were only PR+. The mean age of presentation was 52.6 ± 0.82 yrs and the number of patients reaches a peak between 31 - 50 years (59.4%). Maximum patients were found to be in poor socio-economic class. Invasive duct carcinoma (96.1%) was predominant histology. Majority of the cases (84.5%) had grade-III tumour. 17.8% of total patients presented in stage-I, 42.8% in stage-II and 39.4% in stage-III.
Conclusion: In Northeast India, incidence rate of breast cancer among younger age group has been increasing and more patients were ER/PR negative. Maximum numbers of grade-III tumour were found to be ER/PR negative and as the tumour size increased, ER/PR negativity also increased.
Keyword: Breast cancer, Hormone receptor, Northeast India.
References
- Globocan International Agency for Research on cancer, (IARC), section of cancer information.
- Badwe RA, Gupta S. Breast cancer: An Indian perspective. Natl Med J India. 2011;24:193–7.
- Ghoncheh M, Momenimovahed Z, Salehiniya H. Epidemiology, incidence and mortality of breast cancer in Asian Pac J Cancer Prev. 2016;17:47–52.
- National Centre for Disease Informatics and Research, National Cancer Registry Programme, ICMR. Three Year Report of Population Based Registries, 2009–2011. Bangalore, India: NCDIR-NCRP (ICMR);
- Fisher ER, Sass R, Fisher B, et al. Pathologic findings from the National Surgical Adjuvant Breast Project for breast cancer (Protocol 4): discrimination for tenth year treatment failure. Cancer 1984;53:712-23.
- Carter CL, Allen C, Henson Relation of tumor size, lymph node status and survival in 24,740 breast cancer cases. Cancer 1989;63:181-17.
- Fletcher DM. Tumors of the breast. In: Diagnostic histopathology of tumors; Elsevier, third edition, 2007:942.
- Rosen PP, Harris JR, Hellman S, et al. Breast disease. Philadelphia JB Lippincott, 1987;181-5.
- Bloom JHG, Richardson Histologic grading and prognosis in Breast Cancer. Br J Cancer 1957;9:359-77.
- Henson DE, Ries L, Freedman LS, et Relationship among outcome, stage of disease and histologic grade for 22,616 cases of breast cancer. Cancer 1991;68:21422149.
- Elston CW, Ellis IO, et al. Pathological prognostic factors in breast The role of histological grade in breast cancer: experience from a large study with long-term followup. Histopathology 1991;19:403-10
- Rastelli F, Crispino S. Factors predictive of response to hormone therapy in breast cancer. 2008;94(3):370–83.
- Mohamed FZ, Darwish H, Belal AM, Rajek WY. Some tumor markers and hormonal receptors as Prognostic Parameters of Breast Cancer. Indian J Res 2015;4(2):199-202.
- Suvarchala SB, Nageswararao R. Carcinoma breast- histopathological and hormone receptors correlation. J Biosci Tech 2011;2(4):340-8.
- Suzuki T, Miki Y, Nakamura Y, Moriya T, Ito K, Ohuchi N, et al. Sex steroid producing enzymes in human breast cancer. Endocr Relat Cancer 2005;12(4):701-20.
- Rao M, Joshee R, Deval M, Sethi N. Clinico-morphological profile in breast cancer patients in a tertiary care hospital in western J Evolution Med Dent Sci. 2016; 5(4):262-5.
- Shrivastava N, Gupta R, Gaharwar A P Clinco-pathological presentation of carcinoma of breast at tertiary care centre in vindhya region, rawa, Madhya Pradesh, india. Int Surg j. 2016; 3(3):1156-62.
- Mahapatra M, Satyanarayana S. Evalution of clinic: pathologic ndings of breast carcinoma in a general hospital in southern Indian J Cancer. 2013; 50(4):297-301.
- Shoeb MFR, Pinate AR, Shingade Risk factors and clinical presentations of breast cancer patients: a hospital based study. Int Surg J. 2017; 4(2):645-9.
- Vedasree MK, Rajalakshmi Clinico-pathological study of breast carcinoma with correlation to hormone receptor status & HER2/neu. Indian J Pathol Oncol. 2016;3(4):690-5.
- Agrawal KH, Rajderkar SS. Clinico-epidemiological prole of female breast cancers and its important correlates: a hospital based study. Natl J Community Med. 2012; 3(2):316-20.
- Amgiasvasanth M, Patil PS. Prole of breast cancer patients attending a tertiary care centre: a cross-sectional study. Int J Community Med Public Health. 2016; 3(3):663-7.
- Mench K, Phira A clinic-demographic study of patients with carcinoma of breast at tertiary health care centre. Int Med J. 2016; 3(10):884-8.
- Taran R, Singla D, Kumbhaj P, Chitalkar PG, Gumdal V. Retrospective study of hormone receptor status in breast cancer patients in central India. Natl J Med Res. 2016;6(2):143-5.
- Rajan G, Culas TB, Jayalakshmy PS. Estrogen and progesterone receptor status in breast cancer: a cross-sectional study of 450 women in Kerala, South India.World J Surg Oncol. 2014;12:120.
- Kaul R, Sharma J, Minhas SS, Mardi K. Hormone receptor status of breast cancer in the Himalayan region of Northern India. Indian J Surg. 2011;73(1):9-12.
- Sofi GN, Sofi JN, Nadeem R, Shiekh RY, Khan FA, Sofi AA et al. Estrogen receptor and progesterone receptor status in breast cancer in realtion to age, histological grade, size of lesion and lymph node involvement. Asian Pac J Cancer Prev. 2012;13(10):5047-52.
- Kamil M, Khalid I, Hashim H, Biswas M, Kaur G, Islam R. Association of carcinoma breast: grade and estrogen progesterone receptor expression. JCPSP.2010; 20(4):250-2.
- Pathak TB, Bashyal R, Pun CB, Shrestha S, Bastola S, Neupane S, et al. Estrogen and progesterone receptor expression in breast carcinoma. JPN. 2011;1(2):100-3.
- Bogarapu CB, Vayalapalli MR, Bendi H, Mantra A retrospective study on the incidence of breast carcinoma in a tertiary care hospital. Int J Contemp Med Res. 2016; 3(6):1714-6.
- Das N, Debbarma A, Saha Evaluation of clinico-pathological study of breast cancer in rural population. IOSR J Dental Med Sci. 2016; 15(9):67-9.
- Desai SB, Moonim MT, Gill AK, Punia RS, Naresh KN, Chinoy RF. Hormone receptor status of breast cancer in India: a study of 798 tumours. Breast. 2000;9(5):267-70.
- Eerola H, Aittomaki K, Seljavaara S, Nevanlinna H, Smitten Hereditary breast cancer and handling of patients at risk. Scand J Surg. 2002;91:280-7.
- Chatterjee K, Bhaumik G, Chattopadhyay B. Estrogen receptor and progesterone receptor status of breast cancer patients of eastern India: A multi-institutional study. South Asian J Cancer. 2018;7(1):5-6.
- Kakarala M, Rozek L, Cote M, Liyanage S, Brenner DE. Breast cancer histology and receptor status characterization in Asian Indian and Pakistani women in the U.S. –a SEER analysis. BMC Cancer. 2010;10:191.
- Aryandono T, Harijadi, Soeripto. Hormone receptor status of operable breast cancers in Indonesia: correlation with other prognostic factors and survival. Asian Pac J Cancer Prev. 2006;7:321-4.
- SEER*Stat database. [ http://seer.cancer.gov/statfacts/html/breast.html]
- Kuraparthy S, Reddy KM, Yadagiri LA, Yutla M, Venkata PB, Kadainti SVS, Reddy RPV. Epidemiology and patterns of care for invasive breast carcinoma at a community hospital in Southern India. World J Surg Oncol. 2007;5:56. doi: 10.1186/1477-7819-5-56.
- Shet T, Agrawal A, Nadkarni M, Palkar M, Havaldar R, Parmar V, Badwe R, Chinoy RF. Hormone receptors over the last 8 years in a cancer referral center in India: what was and what is? Indian J Pathol Microbiol. 2009;52:171–174.
- Kumar V, Tewari M, Singh U, Shukla HS. Significance of Her-2/neu protein over expression in Indian breast cancer patients. Indian J Surg. 2007;69:122–128.
Corresponding Author
Dr Neeta Sinam
Address- Rajprinee Sangai, Chingmeirong, Imphal East-795010, Manipur, India
Phone no. -8729877666, 7005705311, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v7i1.178
