Abstract

Introduction: central nerves system neoplasm (CNS) manifest prominently by metastatic tumor. Metastatic CNS tumors are major cause of morbidity and mortality. Pathologist with small amount of tissue and within stipulated time give diagnosis by squash studied. The studied is carried out to study the metastatic brain tumor by squash studied and correlating with H&E.

Material and Methods: Operated CNS tumors biopsy received in department of pathology MR medical college Kalaburgi from BTGH Kalaburgi over period of twelve months from 1 April 2017 to 31 March 2018 examined isolated the cases of metastatic tumors. Fresh viable tissue is crush to make squash smears. Remaining tissue fixed with formalin and paraffin section is made correlate with squash cytology. Immunohistochemistry carried out whenever necessary.

Results: Present study showed sixteen cases of metastatic tumor. Maximum number of cases found in age group of 41 to 50 years age groups. Male and Female ratio approximate 0.7:1 seven cases are male and nine cases are of female. There is female predominance in this study. Site of metastasis in central nervous system are six in spinal cord, five cases in frontoparital region, three in cerebellum and two cases in occipital region.

Primary site of metastatic tumor are five cases of adenocarcinoma of colon, four cases of lung squamous cell carcinoma, four cases of thyroid, one case each of nasopharyngeal carcinoma, seminoma and prostate.

Conclusion: In central nerves system metastatic tumor Squash technique is an important diagnostic tools when accuracy is correlated with paraffin fixed H&E satin histopathological procedure.