Abstract

Background: Preeclampsia is associated with hypocalciuria due to derangement in calcium metabolism associated with this condition. Urinary calcium Creatinine ratio is easily measurable, most effective then with spot urine sample compared with other methods that are expensive, time consuming, required specialized equipment & involving complex procedures. The present study will help us in evaluating the role of urinary calcium Creatinine ratio as an effective screening method for prediction of preeclampsia.

Material & Methods: A Hospital based prospective study done on 80 women who attended the department of Obstetrics and Gynaecology, SMS medical college, Jaipur for routine antenatal care, over a period of 1 year between 16-20 weeks of gestation were included in the study after obtaining informed consent. A spot urine sample was collected for estimation of calcium and creatinine. Calcium was determined by O Cresolphthalein complex reaction and creatinine was estimated by Jaffes method. All these women were followed up till delivery.

Results: The gestational age at weeks in study group was 37.07 weeks & 43.48 weeks in control group. Majority of cases had normal delivery in both groups (85%). Only 15% patients had cesarean delivery, out of which 4 in pre-eclampsia patients and 8 in normal patients. The sensitivity of CCR test was found to be 92.85% and specificity 95.45%. The positive predictive value was 81.25 and the negative predictive value was 98.43.

Conclusion: Screening test for preeclampsia is very essential to prevent complications of preeclampsia, which is a major cause for maternal and fetal mortality and morbidity.

Keywords: Preeclampsia, Urinary calcium Creatinine ratio, Morbidity, mortality.