Abstract
Background: Neoadjuvant chemotherapy is currently established as a standard therapeutic approach for patients with large (>2 cm) and locally advanced breast cancer. The histopathological evaluation of tumor response is the gold standard.
Methods: Histopathologic examination was done in 44 MRM specimen received in the department of pathology over a period of 1 year from August 2017 to July 2018.
Results: 44/44 cases are of female breast. Mean age of patient is 50 years. Mean size before CT was 56.14 cm2 and after CT was 29.40 cm2. In the present study 18% cases show complete pathologic response and 84% cases show incomplete response.
Conclusion: Characteristic pattern of changes observed after histopathological examination of tumor bed are cellular fibrous tissue, reactive lymphocytic infiltration, haemosiderin laden macrophages, areas of coagulative necrosis, stromal hyalinization, dystrophic calcification.
Keywords: Neoadjuvant chemotherapy, breast carcinoma, pathologic response.
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Corresponding Author
Dr Sandhya Verma
Address- R-11, Street no. 3, Dubey colony, Mowa Raipur Pin Code:492007, India
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DOI: https://dx.doi.org/10.18535/jmscr/v7i1.104
