Abstract
Background: Multiple myeloma is a haematological malignancy with varying clinical presentations. Microvessel density (MVD) and proliferation markers are used in predicting prognosis of multiple myeloma patients. Microvessel density was assessed using CD 34 immunostaining and proliferation marker by Ki 67 index. These parameters are correlated with various prognostic markers in multiple myeloma like stage of the disease.
Material & Method: A cross sectional study was done in the Department of Pathology, in a Tertiary care centre in central part of Kerala during a period of 18 months (1/ 2/2014 - 30/7/2015). 30 newly diagnosed cases of multiple myeloma were included in the study. Clinical, haematological, radiological and biochemical investigations collected. Immunohistochemisrty for microvessel density and Ki 67 index were done on bone marrow trephine biopsy. Computerized image analysis was done for MVD assessment. Study was approved by institutional ethical committee.
Results: MVD was higher in patients with higher stage disease. MVD and Ki 67 index showed positive correlation which was statistically significant.
Conclusion: MVD increases with stage of the disease. Patients with high MVD have high proliferation index like Ki 67.
Keywords: Multiple myeloma, MVD, Ki 67 index.
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Corresponding Author
Dr Merin Jose
Address: Kanichikkattil House, Chalakudy P O, Kottat, Thrissur, Kerala, Pin code: 680307, India
Mobile Number: 8289912707, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v7i1.62
