Abstract
Background: Betel quid chewing is ancient, socially acceptable and often combined with tobacco chewing, is a common habit in the Indian subcontinent. A mixture of betel leaf, areca nut, and tobacco chewing is used in many parts of India. Development of malignancy of the oral mucosa and foregut is mainly associated with betel quid chewing. Betel nut chewing is associated with increased production of reactive oxygen species and inflammatory mediators, which could potentially cause kidney damage.
Aim of study: Biochemical changes in betel quid chewers and non chewers in Udaipur district of Rajasthan.
Study Area: The present study was conducted in PMCH, Udaipur.
Study Design: The study was design and undertaken in the Central laboratory of PMCH Udaipur. The cases of this study compare the changes in betel quid chewers and non chewer’s patients.
Statistical Analysis: Data thus collected was entered in Microsoft excel 2007 Worksheet in the form of master chart. These data were classified and analyzed as per the aims and objectives.
Result: During the research study blood examination was done to find out change in biochemical parameters in betel nut chewers and non-chewers groups. The purpose of this study was to comparatively estimate the biochemical parameters of betel quid chewers with their respective controls. The plasma glucose, serum enzymes such as AST, ALT level were increased in betel quid chewers when compared to non-chewers.
Conclusion: A direct association was detected, though the results were less convincing. Furthermore, betel chewing may impose a greater risk than smoking. More effort on developing betel chewing cessation programs is urgently warranted.
Keywords: AST, ALT, Serum Glucose, Betel quid chewers, Non-chewers, Biochemical analysis.
References
- IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Betel-quid and areca-nut chewing and some areca-nut-derived nitrosamines.IARCMonogrEvalCarcinogRisksHum2004;85:1–334
- Boucher BJ, Ewen SWB, Stowers JM. Betel nut (Areca catechu) consumption and the in duction of glucose intolerance in adult CD1miceand in their F1 and F2 offspring. Diabetologia 1994;37:49–5
- Tung TH, Chiu YH, Wu HM, Boucher BJ, Chen THH. A population based study of the association between areca-nut chewing and type 2 diabetes mellitus in men.Diabetologia2004;47:1776–81.(KCISno.2.)
- Boucher BJ,MannanN.Metabolic effects of the consumption of Areca catechu. Addict Biol 2002;7:103–10.
- Zain RB, Ikeda N, Gupta PC, Warnakulasuriya KAAS, van Wyk CW,Shrestha P, and other. Oral mucosal lesions associated with betel quid, Areca nut and tobacco chewing habits: consensus from a workshop held In Kuala Lumpur, Malaysia, November 25–27, 1996. J Oral Pathol Med 1999; 28(1):1–4
- Greenberg . Glick . Ship. Burket‟s oral medicine. 11th edition,page 100-101.
- Zain R B, Ikeda N, Gupta P C, Warnakulasuriya S, van Wyk C W, Shrestha P, Axell T. Oral mucosal lesions associated with betel quid, areca nut and tobacco chewing habits: consensus from a workshop held in Kuala Lumpur, Malaysia. November 25-27, 1996. J Oral Path Med1999: 28: 1-4.
- Boucher BJ, Mannan N. Metabolic effects of the consumption of Areca catechu. Addict Biol 2002;7:103–10.
- IARC Working Group on the Evaluation of Carcinogenic Risks to Humans., World Health Organization., International Agency for Research on Cancer. Betel-quid and areca-nut chewing and some areca-nut-derived nitrosamines. Lyon, France: IARC Press, 2004.
- Al-Rmalli SW, Jenkins RO, Haris PI. Betel quid chewing elevates human exposure to arsenic, cadmium and lead. J Hazard Mater 2011;190:69–74
- Lee BK, Kim Y. Relationship between blood manganese and blood pressure in the Korean general population according to KNHANES 2008. Environ Res 2011;111: 797–803.
- Knekt P, Alfthan G, Aromaa A et al. Homocysteine and major coronary events: a prospective population study amongst women. J Intern Med 2001;249:461–65.
- Parmar G, Sangwan P, Vashi P, Kulkarni P, Kumar S. Effect of chewing a mixture of areca nut and tobacco on periodontal tissues and oral hygiene status. J Oral Sci 2008;50:57–62
- Fogh-Andersen N, Wimberley PD, Thode J, Siggaard-Andersen O. Direct reading glucose electrodes detect the molality of glucose in plasma and whole blood. Clin Chim Acta 1990; 189: 33-38.
- Henry, R. J., et al., Amer. J. Clin. Path., 34:381 (1960).
- Ramya M, Anuradha R Biochemical Changes In Betel Quid Chewers And Non-Chewers of Kakkarai, Thanjavur District of Tamilnadu in Asian J Pharm Clin Res, Vol 8, Issue 3, 2015, 122-124
Corresponding Author
Nita Sahi
Associate Professor Dept. of Biochemistry Pacific Medical College & Hospital Udaipur (Rajasthan), India
DOI: https://dx.doi.org/10.18535/jmscr/v7i1.60
