Abstract

Granular cell tumor (GCT) is uncommon, mostly benign neoplasm that can affect any organ of the body; immunohistochemical studies showed that it has a Schwann cell origin through the positive identification of S-100 protein. GCT can affect both sexes and in any age. Most common occurrence is during the fourth to sixth decades of life, very rarely it occurs as congenital disease. The common locations are the head and neck, the tongue is affected in 25% of cases but any internal organs can be affected such as larynx, bronchus, stomach, rectum, anus, biliary ducts, pancreas and soft tissues. Malignant GCT is extremely rare, it occurs in only 1–2% of cases. Multiple GCTs occur up to 10%. This paper describes two cases diagnosed with granular cell tumor in uncommon site (hand).