Title: Effect of Ipratropium Bromide and Tiotropium Bromide in Patients Suffers From Chronic Obstructive Pulmonary Disease (COPD), Attending in Tertiary Care Hospital, at S.K.M.C.H., Muzaffarpur
Authors: Dr Gaurav Tiwari, Dr G.P.Singh, Dr Deepak Kumar, Dr Satyendra Pathak
DOI: https://dx.doi.org/10.18535/jmscr/v6i9.192
Abstract
Objective: The aim of present study was to compare the effect of 9 months treatment with inhaled Ipratropium bromide and inhaled Tiotropium bromide on airflow obstruction and symptoms, by assessing clinical improvement as well as alteration on pulmonary function tests in cases of mild to moderate chronic obstructive pulmonary disease (COPD).
Material and Methods: A total of 64 patients of 25-65 year of age group of either sex suffered from mild to moderate chronic obstructive pulmonary Disease (COPD) diagnosed by clinical examination, Pulmonary function tests (FEV1, FEV1/FVC, PEFR, FVC by spirometry) and Routine investigation (CBC, Blood sugar, LFT, KFT, Arterial Blood gas analysis, X-ray chest and ECG) were included in the study. All the patient were randomized into two treatment group, with equal proportion of patients (Group A-32 patients and Group- B 32 patients) on the basis of age, sex, severity of disease and smoking habits. Group A patients received inhalation of Ipratropium bromide 40 micrograms by 6 hourly daily for 9 months and the group B patients received inhalation of Tiotropium bromide 18 micrograms by once daily for 9 months. All the patients were followed up at 1 month, 3 months, 6 month and 9 months interval to monitor and improvements in clinical status, Pulmonary function tests, frequency of acute exacerbation and need of additional drugs. Any adverse effect of drugs and any changes in laboratory parameter were noted.
Results: Inhaled Tiotropium bromide was more effective in compare to Ipratropium bromide in patients with mild to moderate cases of COPD And Both drugs were equally effective in clinical improvements over the period of a months.
Conclusion: It is suggested that Tiotropium bromide (18 micrograms OD) inhalation could be more suitable and acceptable by the patients of COPD due to its longer duration of action and it is more effectiveness as compared to Ipratropium bromide (40 micrograms QID inhalation).
Keywords: COPD, Ipratropium bromide ,Tiotropium bromide, Pulmonary function tests, Asthma.
