Abstract
Methicillin resistant Staphylococcus aureus (MRSA) infections have emerged as one of the most common healthcare acquired infections in the present era. In this study, we report the prevalence and antibiotic susceptibility pattern of MRSA isolates from various clinical samples in a tertiary care hospital.
Various clinical specimens from both outpatients as well as admitted patients were cultured on the suitable culture media and Staphylococcus aureus was identified using standard tests like catalase test, slide and tube coagulase test. All Staphylococcus aureus isolates were tested for their antibiogram pattern by Kirby - Bauer disc diffusion method and MRSA were identified amongst them following CLSI guidelines. The D-test was performed on all Staphylococcus aureus isolates to identify erythromycin induced clindamycin resistance.
The prevalence of MRSA in our study was found to be 60.87%. Linezolid and vancomycin proved to be effective against 96.4% and 100% of MRSA isolates respectively.. Antibiotics with highest resistance against MRSA isolates were penicillin, quinolones (ciprofloxacin, levofloxacin) and ampicillin.. Also, 32.14% of MRSA isolates and 22.22% of MSSA isolates showed erythromycin induced clindamycin resistance in this study. Regular surveillance of hospital associated infections along with strict infection control measures, monitoring antibiotic susceptibility pattern of all MRSA isolates and formulation of definite antibiotic policy should be implemented in the hospitals as control measures against MRSA infections.
Keywords: Staphylococcus aureus, MRSA, cefoxitin, linezolid, vancomycin, Kirby-Bauer disc diffusion method.
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Corresponding Author
Dr Vijay Prakash Singh
Room No.-15, Staff Quarters, K.D. Medical College Hospital & Research Centre,
P.O-Akbarpur, District- Mathura, Uttar Pradesh, India -281406
Phone No: +91-9837039416, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v6i9.153
