Abstract
Background: The aim of the study is to evaluate the cytomorphological pattern and frequency of pathological entities and the role of Fine needle aspiration cytology (FNAC) in the diagnosis of peripheral lymphadenopathies at a tertiary care center in kanchipuram during the period of 18 months (January 2017 to June 2018).
Methods: This is a descriptive study including 150 patients who underwent FNAC evaluation of peripheral lymphadenopathy from the period of January 2017 to June 2018. The patients were analysed to determine the age and sex distribution, anatomical distribution and cytodiagnosis, distribution of cytomorphological patterns.
Results: Among 150 cases, reactive lymphadenitis was the most common cytomorphological pattern 76/150 (50.66%) followed by granulomatous lymphadenitis (56/150, 37.3%) as the second most common diagnosis. Female cases were more in this study (82, 54.7%) than male (68/150, 45.3%), Reactive lympadenitis was more frequent in males and granulomatous lymphadenitis in female patients. Metastatic deposit was common among male (>60 years). Out of 150 cases cervical lymphnodes (100/150, 66.6%) were most commonly involved, followed by supraclavicular (10.6%), axillary (9.3%), submandibular (6%), inguinal (4.6%) and post auricular (2.6%).
Conclusion: FNAC is a simple, minimally invasive, inexpensive and rapid diagnostic tool in the diagnosis of lymphadenopathy. FNAC plays an important role in places where histopathological facilities are not available,in early diagnosis of benign and malignant lesions and also helps in planning early management of lymphadenopthies.
Keywords: Lymph node, Fine needle aspiration cytology, Morphological pattern.
References
- Pocock, Gillian; Richards, Christopher D. (2006). Human physiology : the basis of medicine (3rd ed.). Oxford: Oxford University Press. pp. 252–253. ISBN 978-0-19-856878-0.
- Darnal HK, Karim N, Kamini K, Angela K.The profile of lymphadenopathy in adults and children.Med J Malaysia. 2005;60:590–8. PubMed PMID: 16515110. [PubMed]
- Bazemore AW, Smucker DR. Lymphadenopathy and malignancy. Am Fam Physician. 2002;66:2103–10. PubMed PMID: 12484692. [PubMed].
- Malaker D, Jajoo ILN, Swarup K, Gupta OP, Jain AP, Poflee VW. A clinical evaluation of fine Needle aspiration cytology in the diagnosis of lymphadenopathy. Ind J Tub. 1991:17-9
- Jimenez-Heffernan JA, Vicandi B, Ferrer LP, Hardisson D, Vigner J. Value of fine needle aspiration cytology in the initial diagnosis of Hodgkins disease. Analysis of 188 cases with an emphasis on diagnostic pitfalls. Acta Cytol. 2001;45:300-6.
- Carter TR, Feldman PS, Innes Jr DJ, Frierson Jr HF, Frigy AF. The role of fine needle aspiration cytology in the diagnosis of lymphoma. Acta Cytol. 1988;32(6):848-53
- Shrivastav A, Shah HA, Agarwal NM, Santwani PM, Srivastava G. Evaluation of peripheral lymphadenopathy by fine needle aspiration cytology. A three year study at tertiary center. Journal of Dr NTR University of Health Sciences. 2014;3(2):86-91.
- Mohanty R, Wilkinson A. Utility of fine needle aspiration cytology of lymph nodes. IOSR J Dent Med Sci. 2013;8(5):13-8.
- Sheela KM et al. Reliability of FNAC as a diagnostic tool in lymphadenopathy. Int J Adv Med. 2017 Aug;4(4):1073-1077
- Pandey P, Dixit A, Mahajan NC. The diagnostic value of FNAC in assessment of superficial palpable lymph nodes: a study of 395 cases. Al Ameen J Med Sci. 2013;6 (4):320-7.
- Kumar H, Chandanwale SS, Gore CR, Buch AC, Satav VH, Pagaro PM. Role of fine needle aspiration cytology in assessment of cervical lymphadenopathy. Med J Dr DY Patil University. 2013;6(4):400-4. 11.
- Shilpa G, Nataraju G. Pattern of lymph node diseases in a tertiary level referral center: a cytological study of 943 cases. Inter Biol Med Res. 2013;4(3):3448-52
- Mamatha K, Arakaru SU. Clinicocytological study in evaluating the primary site of tumor in patients presenting with metastatic tumors in lymph nodes. Asian J Pharma Health Sci. 2014;4(2):1001-5.
- Mohan A, Thakral R, Kaur S, Singh S. Fine needle aspiration in metastatic lymphadenopathy - a five year experience in Muzzafarnagar region. J Adv Res Biol Sci. 2013;5(2):172-6.
- Duraiswami R et al. Spectrum of pathologies on FNAC evaluation of peripheral lymph nodes at a tertiary care center in hyderabad: a retrospective study. Int J Adv Med 2017;4:27-33.
- Mohan A, Thakral R, Kaur S, Singh S. Fine needle aspiration in metastatic lymphadenopathy - a five year experience in Muzzafarnagar region. J Adv Res Biol Sci. 2013;5(2):172-6.
Corresponding Author
V.Eswari
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DOI: https://dx.doi.org/10.18535/jmscr/v6i9.116
