Title: A Study for Evaluation of Serum Vitamin D Levels in Patients with type 2 Diabetes Mellitus with or without Complications
Authors: Niraj Agarwal, Dhiraj Kapoor, Pankaj Kumar, R.S. Yadav, Guriqbal Singh, Abhimanyu Patial, Bhagwan Dass, Sayan Malakar
DOI: https://dx.doi.org/10.18535/jmscr/v6i9.115
Abstract
Introduction: One of the important emerging nutritional risk factors recognized for the development of insulin resistance (IR) and T2DM is deficiency of vitamin D. There has been increasing evidence suggesting that vitamin D may play an important role in modifying risk of diabetes. Vitamin D replenishment improves glycaemia and insulin secretion in patients with type 2 Diabetes Mellitus with established hypovitaminosis D, thereby suggesting a role for vitamin D in pathogenesis of diabetes mellitus.
This study determines if there is any association between vit. D deficiency and T2DM
The scarcity of available data and the diversity of climate, culture and dietary habits prevalent in HP prompted us to undertake this study in a sub himalayan region.
Aim and Objective of the Study: To evaluate serum Vitamin D levels in patients with T2DM with or without complications.
Materials and Methods: It was a Cross Sectional study .Study was conducted at Dr. RPGMC Kangra and was conducted over a period of 1 years.
Results: Vitamin D level in patients without microvascular complications was 25.63±13.52 and in patients with microvascular complications the mean vitamin D level was 15.71±9.42. This difference was statistically significant (p≤0.05). Out of the 60 patients with microvascular complications, 40 patients (66.7%) were deficient in vit D, 15 patients (25%) were insufficient in vit D and only 5 patients (8.3%) had sufficient level of vit D. In patients without microvascular complications(total 40), 37.5% were deficient in vit D, 30% were insufficient in vit D and 32.5% had sufficient level of vitamin D
Summary and Conclusion: Patients with type 2 diabetes mellitus had mean vit D level of 19.68±12.20ng/ml which is in the deficient range. Mean vit D levels are significantly lower in patients with microvascular complications (15.71±9.42) than without complications (25.63±13.52).(p<0.05).The prevalence of vit D deficiency in patients with microvascular complications was more than in patients without microvascular complications(66.7% vs 37.5%).Vitamin D levels in patients with poorly controlled diabetes (18.23±12.34) were lower than patients with well controlled diabetes(23.07±11.35) but the difference was not significant. Vit D level decreased with increase in duration of diabetes
Keywords:T2DM:Type 2 Diabetes Mellitus, DPN:Diabetic peripheral neuropathy, Vit D:Vitamin D, VDR: Vitamin D receptor, GFR: Glomerular Filtration Rate
