Abstract
Purpose: To study the factors influencing central corneal thickness in patients diagnosed with primary glaucomas.
Methods: 230 eyes were included in this cross sectional study. Patient parameters were recorded using a prepared questionnaire and complete ocular examination including IOP and gonioscopy was done. CCT was measured using ultrasound pachymeter (Pacscan 300p – Sonomed).
Results: The mean CCT measured in this study was 537.6 ± 39.3 μm. Age was found to have a negative correlation with CCT, with r = -0.38( p< 0.001). There was no significant correlation between gender and CCT. Diabetic patients were found to have higher CCT (555.72 ± 33.81 μm ; p < 0.001). The mean CCT in those with PACG was 568.13 ± 33.78 μm, which was significantly higher than that of patients with POAG (523.76 ± 33.44 μm), with a p value < 0.001. Myopes had a significantly lower CCT than hypermetropes (CCT = 509.72 ± 33.14μm, p < 0.001). IOP by Goldmann applanation tonometry showed a significant positive correlation with CCT with r = 0.78 and p < 0.001.
Conclusion: CCT is significantly affected by age, presence of diabetes mellitus, type of refractive error, type of primary glaucoma and intraocular pressure by Goldmannapplanation tonometer. There is no significant relation between gender and CCT.
Keywords: Central corneal thickness, intraocular pressure, Goldmann applanation tonometer, primary glaucoma.
References
- Goldmann H, Schmidt T. Applanation tonometry [in German]. Ophthalmologica 1957;134:221–42.
- Brandt JD, Beiser JA, Kass MA, et al. Central corneal thickness in the Ocular Hypertension Treatment Study (OHTS). Ophthalmology. 2001; 108(10):1779-1788
- Ehlers N, Bramsen T, Sperling S. Applanation tonometry and central corneal thickness. Acta Ophthalmol (Copenh). 1975;53(1):34-43
- Mohan S, Tiwari S, Jain A, Gupta J, &Sachan S. K. (2014). Clinical comparison of Pulsair non-contact tonometer and Goldmannapplanation tonometer in Indian population. Journal of Optometry, 7(2), 86–90
- Saulius Galgauskas, Grazina Juodkait, Janina Tutkuviene. Age-related changes in central corneal thickness in normal eyes among the adult Lithuanian population, Clinical Interventions in Aging 2014:9 1145–1151.
- Iyamu E, Memeh M. The Association of Central corneal thickness with Intra-ocular Pressure and Refractive Error in a Nigerian Population. Online J Health Allied Scs.2007;3:2
- Su DH, Wong TY, Wong WL. Diabetes, hyperglycemia, and central corneal thickness: the Singapore Malay Eye Study. 2008 Jun;115(6): 964-968.e1.
- Pang CE, Lee KY, Su DH, Htoon HM, Ng JY, Kumar RS, Aung T. Central corneal thickness in Chinese subjects with primary angle closure glaucoma. J Glaucoma. 2011 Sep;20(7):401-4.
- Shah S, Chatterjee A, Mathai M, et al: Relationship between corneal thickness and measured intraocular pressure in a general ophthalmology clinic. Ophthalmology , 1999; 106:2154-2160.
- Moghimi S, Torabi H, Hashemian H, Amini H, Lin Central Corneal Thickness in Primary Angle Closure and Open Angle Glaucoma. Journal of Ophthalmic & Vision Research(2014), 9(4), 439–443.
- Chang SW, Tsai IL, Hu FR, et al. The cornea in young myopic adults.Br J Ophthalmol. 2001;85:916–920.
- Archna Prasad, Kristen Fry, Peter S. Hersh. Relationship of Age and Refraction to Central Corneal Thickness. Cornea 2011;30:553–555
Corresponding Author
Dr A.K.Behera
Asst., Professor, Department of General Surgery
VIMSAR, Burla, Odisha, India
Contact number: 9437303084, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v6i6.171
