Title: A Study on different histological variants of Phyllodes tumour of Breast and Fibroadenoma with special emphasis to differentiate Fibroadenoma from Benign Phyllodes tumour – A Retrospective 2 years study in a Tertiary care centre
Authors: Dr Gopinath Barui, Dr Tripti Das, Dr Santanu Nandy
DOI: https://dx.doi.org/10.18535/jmscr/v6i6.122
Abstract
Background: Fibroadenoma is the most common benign breast tumour in adolescent and young women of child bearing age group arising from the Terminal Duct Lobular Unit (TDLU) and featuring a proliferation of both epithelial and stromal elements. Phyllodes tumours are rare fibro epithelial tumours of the breast tumours account for0.3–1% of all primary tumours of the breast predominantly in middle-aged women. Intracanalicular fibroadenoma with increased stromal cellularity closely mimics benign phyllodes tumour but it has to be differentiated properly as clinical management and prognosis are different in both the cases.
Materials and Methods: A retrospective observational study was done in Department of Pathology, R.G. Kar Medical College and Hospital, Kolkata; over a period of 2 years from January 2016 to December 2017. Total 127 cases of fibroadenoma and 19 cases of phyllodes tumour cases were analyzed.
Results: Out of total 146 cases, 127 cases (87%) were Fibroadenoma and rest 19 cases (13%) were Phyllodes tumours. Out of 19 cases of phyllodes tumours 11 (57.8%) were Benign Phyllodes, 7 (36.8%) were Borderline Phyllodes and 1(5.4%) was Malignant phyllodes. Fibroadenomas were most common in the 11-20 yrs (45.67%) age group, followed by 21-30 yrs (36.22%), while phyllodes were more common in 41-50 yrs (36.84%) age group. Fibrocystic changes were present in 13.39% cases of fibroadenoma. Fibroadenoma and Benign Phyllodes tumour of breast were differentiated on the basis of 3 histological feature i.e. stromal cellularity, cellular pleomorphism and mitotic activity.
Conclusion: There is various histomorphological variants of fibroadenoma and 3 types of phyllodes tumour; which were studied and this knowledge is very helpful where there is overlapping features of both the tumours and chance of confusion is present. Special emphasis was given to differentiate fibroadenoma from benign phyllodes.
Keywords: Phyllodes tumour, fibroadenoma, breast.
