Abstract
Pregnancy induced hypertension (PIH) is the most common disorder of pregnancy affecting approximately 10-17% of pregnancies and is a significant cause of maternal and fetal morbidity and mortality globally. The incidence of PIH in India ranges from 5% to 15%. Profound changes in the coagulation and fibrinolytic system occur during normal pregnancy causing a hypercoagulable state. Recent studies suggest that platelet parameters like platelet indices are markers of platelet activation and are rapid, cheap, most simple and cost effective method for prediction of PIH, way before the appearance of derangements in PT, APTT, TT values. Hence In our study we aimed to investigate the association between severity of preeclampsia and mean platelet volume. In this study MPV was found to be valuable in cases of multigravida subgroup. These indices gives proof of the role of platelet indices in diagnosing severity of preeclampsia and that the peripheral smear alone is not helpful and that these are simple ,easy, rapid and cheap method to incorporate platelet indices in diagnosing preeclampsia.
Keywords: pregnancy, preeclampsia, Mean platelet volume, platelet
References
- Jyothi Shetty1, Sudha Rao2, M H Kulkarni2; Hematological changes in pregnancy-induced hypertension international journal of scientific study | august 2016 | vol 4 | issue 5
- Feroza Sultana1, Raja Parthiban2, Shameem Shariff3;Thrombocytopenia in pregnancy induced hypertension;Journal Of Medical Sciences And Health/May-Aug 2015/volume 1/issue 2
- Anand S, Kirshnanand. Perinatal outcome in growth retarded babies born to normotensive and hypertensive mothers: A prospective study. People’s J Sci Res 2012;5:24-8.
- Sameer MA, Meshram DP, Deshpande SA, Sadhu D, Pandit S.;Role of platelet count as important prognostic marker in pregnancy induced hypertension.; IOSR J Dent Med Sci2014;13:39-43.
- B.M. Hypertension in pregnancy. Clinical Obstet Gynecol, 1999:421-436.
- Nobis PN1, Hajong AEclampsia in India Through the Decades.j obstet gynecol india 2016 Oct;66(Suppl 1):172-6. doi: 10.1007/s13224-015-0807-5. Epub 2016 Jan 8.
- Gibson G, Hunter D, Neame PB, Kelton JG. Thrombocytopenia in pre-eclampsia and eclampsia. Semin Thromb Hemost. 1982;8:234-247.
- Pritchard JA, Cunningham FG, Mason RA. Coagulation changes in eclampsia: their frequency and pathogenesis. Am J Obstet Gynecol. 1976;8:855-864.
- Burrows RF, Hunter DJS, Andrew M, Kelton JG. A prospective study investigating the mechanism of thrombocytopenia in preeclampsia. Obstet Gynecol. 1987;70:334-338.
- Saleh AA, Bottoms SF, Welch RA, Ali AM, Mariona FG, Mammen EF Preeclampsia, delivery and the hemostatic system. Am J Obstet Gynecol. 1987;1 57:331-336.
- Mohapatra S, Pradhan BB, Satpathy UK, Mohanty A, Pattnaik JR. Platelet estimation: Its prognostic value in pregnancy induced hypertension. ;Indian J Physiol Pharmacol 2007;51:160-4.
- Karateke, R.K. Kurt, A. Baloglu Relation of platelet distribution width (PDW) and platelet crit (PCT) to preeclampsia Ginekol Pol., 86 (5) (2015), pp. 372-375
- Singer CR, Walker JJ, Cameron A, Fraser C. Platelet studies in normal pregnancy and pregnancy-induced hypertension. Clin Lab Haematol. 1986; 8(1):27-32.
- Walker JJ, Cameron AD, Bjornsson S, Singer CR, Fraser C. Can platelet volume predict progressive hypertensive disease in pregnancy.Am J Obstet Gynecol. 1989 Sep; 161(3):676-9.
- Dogru Y H, Yucel N, Pelit CF, Bolat G (2011) The importance and evaluation of mean platelet volume on the severity of preeclampsia. Prenatal Journal 19:108-13.
- Amita K1,*, Nithin Kumar H2, Shobha SN3, Vijay Shankar4;The Role Of Platelet Parameters As A Biomarker In The Diagnosis And In Predicting The Severity Of Preeclampsia ;Indian Journal of Pathology and Oncology, April-June 2015;2(2);57-60
- Thakur Bhavana, Kulkarni Vishal, Thakur Prashant; Platelet Indices in Pregnancy Induced Hypertension;J Cont Med A Dent. September-December 2016;4(3):20-26.
- Vamseedhar A, Srinivasa K, Santosh K Y, Suresh DR. (2011) Evaluation of platelet indices and platelet counts and their significance in pre-eclampsia and eclampsia. Int J Biol Med Res 2:425 – 28.
- Rabia Parveen Siddiqui, Kajal Chandrakar, Ruchi Varma, Shruti Shrivastava. “Study on Platelet Indices in Pregnancy Induced Hypertension”. Journal of Evidence based Medicine and Healthcare; Volume 2, Issue 44, November 02, 2015; Page: 8035-8040, DOI: 10.18410/jebmh/2015/1079
- Akhila N R*1, Lingaraj Jayalakshmi2 and Komala Devi S D3 Study of Mean Platelet Volume in Gestational Hypertension and Normal Pregnancy ; International Journal of Biomedical Research 2015; 6(06): 366-369.
- Altinbas S, Togrul C, Orhan A, Yucel M, Danisman N (2012) Increased MPV is not a significant predictor of preecalmpsia during pregnancy. J clin Lab Anal 26:403-06.
- Kashanian M, Hajjaran M, Ghasemi A, Khatami E S (2012) Evaluation of the diagnostic value of the first and third trimester maternal mean platelet volume (mpv) for prediction of pre-eclampsia. Razi Journal of Medical Sciences 19;1-9.
- Ceyhan T, Beyan C, Başer I, KaptanK, Güngör S and Ifran A (2006) the effect of pre-eclampsia on complete blood count, platelet count and mean platelet volume. Annals of Hematology 85:320-22.
- Vagdatli E, Gounari E, Lazaridou E, KatsibourliaE, Tsikopoulou F, and Labrianou I (2010) Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 14:28–32.
Corresponding Author
Dr Priya Vijaykumar Gameti
Resident, Department of Pathology
Government Medical College, Surat, Gujarat, India
DOI: https://dx.doi.org/10.18535/jmscr/v6i6.101
