Abstract
Asthma is an inflammatory disease of the small airways characterized by episodic, reversible bronchial obstruction, polyphonic wheeze, dyspnoea, and cough which may be relieved spontaneously or as a result of therapy. Asthma cannot be cured but it could be controlled. Combined medications possess both reliever and controller properties are very good for asthmatic treatment. Siddha herbo mineral preparations are bio-safe and have its own fast acting properties to control broncho constriction and relieves from asthmatic symptoms early. And they probably don’t cause any adverse drug reactions. Vasanthakusumakara Mathirai (VKM) was indicated for respiratory illness includes sneezing, fever and bronchial asthma. To evaluate the Siddha herbo mineral drug VKM by exposing guinea pig in histamine aerosol for bronchodilator activity. Four group each group contain six animal. All the doses were given orally once a day for 5 days. Prior to drug treatment each animal was placed in the histamine chamber and exposed to 0.2 % histamine aerosol. The pre convulsive time (PCT) was determined from the time of exposure to onset of convulsions. These animals were again subjected to histamine aerosol after 1hour of drug administration and PCT was determined, then results were tabulated. Hence the test drug has significant effect on bronchodilator and proves to be the best drug for treating asthma.
Keyword: Bronchodilator, Vasanthakusumakara Mathirai, Siddha, Pre-convulsion time.
References
- World health organisation, Asthma Fact Sheet (Updated 2013 Nov.; Cited 2014 May 8) http://www.who.int/mediacentre/factsheets
- Johnston SL, Holgate ST. Asthma. Critical debates. London: Blackwell Science: 2003
- Alagappan. Manual of practical medicine. Jaypee Brothers Medical Publisher: 3rd edition: 2007: 218
- Kumar P, Clark M. Kumar & Clark Clinical Medicine. W.B. Saunders London: 5th edition: 2004: 874-884
- Rakesh kumar et al. Pharmacological evaluation of calendula officinalis L. On bronchial asthma in various experimental animals. Int J Nutr Pharmacol Neurol Dis 2014: vol.4(2): 95-103
- World Health Organization fact sheet no.206
- Kambayashi T, G.A. Proximal signalling events in FC RI mediated mast cell activation. J. Allergy and Clinical Immunol 2007: 119: 544-552.
- Church M K, F Levi-Schaffer. The human mast cell. J. Allergy and Clinical Immuno 1997: 99: 155-160
- World Health Organisation, Asthma, 10 Facts on asthma. (Updated 2013 Nov; Cited 2014 May 8) http://www.who.int/features/factfiles/asthma
- asthma.org.uk, Treatment and Side effects of asthma medicines. (Cited 2014 May 8) http://www.asthma.org.uk/knowledge-banktreatment-and-medicines-side-effects-of-asthmamedicines
- Kamboj VP. Herbal Medicine. Curr Sci 2000: 78: 35-39
- S P Ramachandran. Yugimuni vaithiya chinthamani 800. Thamarai Noolagam: First Edition: 1998: 269
- Kuppusami Mudhaliyar KN, Uthamarayan KS. Siddha Vaithiya Thiratu. Indian Medicine and Homeopathy: First edition: 1933: 40
- Indhumathi, A.Shanuvas, M.Pitchiah kumar. Screening of potential functional group, particle size and heavy metal analysis present in Siddha formulation “Vasanthakusumakara Mathirai”. World Journal of Pharmacy and Pharmaceutical Sciences: 2018: 7(6): 1589-1598.
- Sagar R, Sahoo HB et al. Pharmacological evaluation of calendula officinalis L. on bronchial asthama in various experimental animals. Int J Nutr Pharmacol Neurol Dis: 2014: 4: 95-103
Corresponding Author
Dr M.Indhumathi
SRF, AYUSH Project, Saveetha Medical College, Thandalam, Chennai – 602 105
Ph.No: 9500904655, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v6i6.63
