Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver related morbidity. It occurs even more frequently in patients with metabolic syndrome. Patients with NAFLD have an increased risk of cardiovascular disease because these diseases share several risk factors and surrogate markers like obesity, insulin resistance, diabetes mellitus type 2, hypertension and hyperlipidemia.
Objectives: To study the various biochemical parameters in non-alcoholic fatty liver disease patients.
Material and Methods: The present study was conducted in the Department of Medicine M.G.M. Medical College & M.Y. Hospital, Indore on 65 patients with ultrasonographic finding of fatty liver disease with no history of alcohol. Various biochemical parameters like serum cholesterol, serum triglycerides, ALT, AST were measured and recorded. For analysis, statistical software SPSS latest Version 20.0 was used. The results were analysed using the appropriate statistics.
Results: In our Study we found that 65% patients had elevated Triglyceride level and only 29% patients had hypercholesterolemia. We also found that 49% patients had elevated ALT level and only 26% patients had elevated AST level.
Conclusion: our study shows higher triglyceride level is more associated with NAFLD than cholesterol level but the values of ALT and AST were unremarkeble in cases of NAFLD.
Keywords: biochemical parameters, serum cholesterol, serum triglycerides, AST, ALT, non-alcoholic fatty liver disease.
References
- Ludwig J, Viggiano TR, McGill DB, Oh BJ. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc. 1980; 55(7): 434-8.
- Marceau P, Biron S, Hould FS, Marceau S, Simard S, Thung SN, Kral JG. Liver pathology and the metabolic syndrome X in severe obesity. J Clin Endocrinol Metab. 1999; 84(5): 1513-7.
- Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S, Ouchi N, Arita Y, Okamoto Y, Shimomura I, Hiraoka H, Nakamura T, Funahashi T, Matsuzawa Y; Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol. 2003; 23(1): 85-9.
- Bugianesi E, Leone N, Vanni E, Marchesini G, Brunello F, Carucci P, Musso A, De Paolis P, Capussotti L, Salizzoni M, Rizzetto M. Expanding the natural history of non-alcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenter-ology. 2002; 123(1): 134–140.
- Singh SP, Nayak S, Swain M, Rout N, Mallik RN, Agrawal O, Meher C, Rao M. Prevalence of nonalcoholic fatty liver disease in coastal eastern India: a preliminary ultrasonographic survey. Trop Gastroenterol 2004; 25(2): 76-79.
- Tsochatzis EA, Manolakopoulos S, Papatheodoridis GV, Archimandritis AJ. Insulin resistance and metabolic syndrome in chronic liver diseases: old entities with new implications. Scand J Gastroen-terol. 2009; 44(1): 6-14.
- Adams LA, Sanderson S, Lindor KD, Angilo P. The histological course of non alcoholic fatty liver disease. A longitudinal study of 103 patients with sequential liver biopsies, J hepatol 2005; 42 : 132-8.
- Agrawal R, Mishra S, Dixit VK, Rai S. Association of non-alcoholic fatty liver disorder with obesity. Indian J. Prev. Soc. Med. 2009; 40(3&4): 126-129.
- Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, Grundy SM, Hobbs HH. Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity. Hepatology 2004; 40: 1387-1395.
- Verma S, Jensen D, Hart J, Mohanty SR. Predictive value of ALT levels for non-alcoholic steatohepatitis (NASH) and advanced fibrosis in non-alcoholic fatty liver disease (NAFLD). Liver Int. 2013; 33(9): 1398-405
- Kim EJ, Kim B-h, Seo HS, Lee YJ, Kim HH, Son H-H, Choi Mh. (2014) Cholesterol-Induced Non-Alcoholic Fatty Liver Disease and Atherosclerosis Aggravated by Systemic Inflammation. PLOS ONE 2014; 9(6): e97841.
- Carter-Kent C, Zein NN, Feldstein AE. Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: implications for treatment. Am J Gastroenterol. 2008; 103: 1036-1042.
- Sanyal AJ, Campbell Sargent C, Mirshahi F, Rizzo WB, Contos MJ, Sterling RK, Luketic VA Shiffman ML, Clore JN. Nonalcoholic steatohepatitis: association of insulin resistance and mitocohondrial abnormalities. Gastroenterology 2001; 120(5): 1183-92.
Corresponding Author
Prashant Khuraiya
Senior Resident, Department of Medicine
M.G.M. Medical College, Indore (M.P.), India
DOI: https://dx.doi.org/10.18535/jmscr/v6i6.04
