Objectives: To study the association of thyroid hypofunction with increasing age in pregnant women with hypertension

Design: Prospective, observational, cohort study.

Setting: Study was carried out in Department of Obstetrics and Gynaecology, S.S.M.C and associated G.M. Hospital Rewa, Madhya Pradesh during the period of 1^st August 2015 to 31^st July 2016.

Study Population: In the study 200 women were recruited in which 100 women were taken as cases and 100 were taken as control. Study population was selected randomly from women visiting to the outdoor and those admitted in antenatal ward.

Participants - Cases: Women visiting the outdoor or those admitted in antenatal ward with diagnosis of gestational hypertension or preeclampsia where the case was defined on the basis of inclusion and exclusion criteria

Controls: Women visiting the outdoor or those admitted in antenatal ward without gestational hypertension or preeclampsia.

Main Outcome Measure(s): Results: Incidence of hypothyroidism increased with age from 12.5%(1 out of 18) , to 12.8%(6 out of 47), then to 41.9%(13 out of 31) and then further to 50% (7 out of 14) in age group <20 years, 20-24 years, 25-29 years and ≥ 30 years respectively.

Conclusions: A positive association is present between increasing ageand incidence of hypothyroidism (clinical and subclinical) in antenatal patients having hypertension. This shows that the incidence of hypothyroidism increases with again women with hypertension in pregnancy and age is significantly associated with hypothyroidism in the study group.Keywords: Hypertension, Thyroid Hypofunction, Gestational Hypertension ,Preeclampsia

1. Negro R, Farmoso G, Mangieri T, et al. Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complications. J ClinEndocrinol Metab. 2006; 91:2587–91.
2. Dukkitt K, Harrington D. Risk factors for preeclampsia antenatal booking: Systemic review of controlled studies. BMJ. 2005; 330:565-567
3. Dutta DC. Hypertensive disorders in pregnancy. In Text book of Obstetrics including perinatology and contraception. 6th edition. Calcutta: New central book agency ; 2004: 221-242.
4. Borst GC, Eil C, Burman KD. Euthyroidhyperthyroxinemia. Ann Intern Med. Mar 1983;98(3):366-78.
5. Stagnaro green A. Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and Postpartum. 2011 ;21(10) :1081-1125.
6. Shobha G, Rajeswari B, Srividya R. Prevalence of hypothyroidism in antenatal women attending OPD at Gandhi hospital. Panic Journ Med Scien.2015 Dec;5(3):150-152.
7. Haddow JE, Palomaki GE, Allan WC, Williams JR, Knight GJ, Gagnon J, et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 1999;341:549–55.
8. Vaidya B, Antony S, Bilosum. Detection of thyroid disfunction in early pregnancy: Universal screening of high risk targeted case finding. J Clin Endocrinol Metab. 2007;92(1):203-7

Dr Kalpana Yadav

Assistant Warden Quarter, Shristi Hotel, Hospital campus,

S.S. Medical CollegeRewa (M.P.)

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