Title: Study of coagulation profile in hepatic disorders in a Tertiary Care Centre
Authors: Takutila M Ozukum, Sandhya Gulati, Nidhi Sharma, Gaurav Kumar Gupta
DOI: https://dx.doi.org/10.18535/jmscr/v6i3.192
Abstract
Introduction: Liver plays the important role of synthesis of coagulation and anti coagulation proteins. Thus derangement of liver functions can lead to alteration and abnormal balance of these pathways.
Materials and Methods: The study included 170 cases of diagnosed liver diseases in the gastroenterology ward. PT, APTT and platelet count were the parameters evaluated.
Results: Out of the total 170 cases, 130 (76.50%) cases had altered coagulation profile. Out of 115 cases of liver cirrhosis, PT, APTT and platelet count were altered in 71.3%, 81.7% and 52.2% respectively. In 24 cases of liver abscess, PT, APTT and platelet count were altered in 58.3%, 58.3% and 4.1% respectively. In the remaining 31 cases, PT, APTT and platelet count were altered in 40%. 36.7% and 12.9% respectively.
Conclusion: Coagulation profile was found to be significantly altered in patients with liver disease.
Keywords: Liver, coagulation, platelet, prothrombin.
References
- Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL et al. Harrison's Principle of internal medicine19th McGraw Hill. 2012;2:2520-31.
- Stephen H. Caldwell, Maureane Hoffman, Ton Lisman, B. Gail Macik, Patrick G Northup, K. Rajender Reddy et al. Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management. Hepatology. Oct 2006;44(4):1039-46.
- Sohail Ahmed Siddiqui, Ahmed M, Muhammad Hanif Ghani, Muhammad Anwar Menon, Ghulam Mustafa, Muhammad Aslam Ghori. Coagulation abnormalities in patients with chronic liver disease in Pakistan. Journal of Pakistan Medical Association. April 2011;61(4):363-7.
- Varnika Rai, Neeraj Dhameja, Sandip kumar, Jyoti Shukla, Rajeev Singh, Vinod Kumar Dixit. Haemostatic Profile of Patients with Chronic Liver Disease- its Correlation with Severity and Outcome. Journal of Clinical and Diagnostic Research. Aug 2017;11(8):24-6.
- Jaeyoung Cho, Sun Mi Choi1, Su Jong Yu, Young Sik Park, Chang-hoon Lee, Sang-min Lee. Bleeding complications in critically ill patients with liver cirrhosis. korean Journal of Internal Medicine. 2016;31:288-95.
- Andreas Drolz, Thomas Horvatits, Kevin Roedl, Karoline Rutter, Katharina Staufer, Nikolaus Kneidinger. Coagulation parameters and major bleeding in critically ill patients with cirrhosis. Hepatology. 2016;64:556-68.
- Kyung-Hwa Shin, M.D., In-Suk Kim, M.D., Hyun Ji Lee, M.D., Hyung-Hoi Kim, M.D., Chulhun L. Chang, M.D., Young Mi Hong, M.D. Thromboelastographic Evaluation of Coagulation in Patients With Liver Disease. Annals of Laboratory Medicine. 2017;37:204-12.
- Dhaval O. Mangukiya, Jitendra R. Darshan, Vijay K. Kanani, Saurabh T. Gupta. A Prospective Series Case Study of Pyogenic Liver Abscess: Recent Trands in Etiology and Management. Indian Journal of Surgery. September–October 2012;74(5):385–90.
- Xue-Ping Wang, Min- Jie Mao, Zhong-Lian He, Lin Zhang, Pei-Dong Chi, Jia-rui Su. A retrospective discussion of the prognostic value of combining prothrombin time(PT) and fibrinogen(Fbg) in patients with Hepatocellular Carcinoma. Journal of Cancer. 2017;8(11):2079-87