Abstract
Aim & Objective: To report the toxicity and outcome of intraluminal brachytherapy(ILBT) boost following chemoradiation (CRT) in the radical treatment of patients with Squamous cell carcinoma of the esophagus.
Patients & Methods: Patients with non-metastatic squamous cell carcinoma of the esophagus who were not candidates for surgery, were enrolled for this prospective observational study. They were treated with external radiation (44 Gy in 2Gy/day) with concurrent weekly cisplatin and 5-fluorouracil followed by brachytherapy boost. Acute and late toxicities, local control and overall survival were analyzed.
Result: Thirty patients with mean age of 53 years were enrolled in this study. Mean length of esophagus involved was 6cm. Two (6.6%) patients experienced grade 3 event – esophagitis, while 4(13.3%) patients developed esophageal perforation, of which 2 patients had gross residual disease, while two patients were locally disease free. Two patients (6.6%)died due to treatment related causes – esophageal perforation. Three (10%)patients developed grade3 stricture and symptomatic ulcers which required serial esophageal dilatation. Complete response as assessed at 3 months was 76.6%. The disease free survival and the overall survival at 1 year was 65.4% and 74.8% respectively.
Conclusion: In patients with Squamous cell carcinoma of the esophagus, radical chemoradiation with brachytherapy boost is well tolerated, with low incidence of severe complications and offers good survival.
Keywords: Esophageal neoplasms, Chemoradiotherapy, Brachytherapy, Squamous cell carcinoma.
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Corresponding Author
Dr Arun Sankar Sudha, MD
Division of Radiation oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India
Email: This email address is being protected from spambots. You need JavaScript enabled to view it., This email address is being protected from spambots. You need JavaScript enabled to view it., Phone: +91-9249554405
DOI: https://dx.doi.org/10.18535/jmscr/v6i3.174
