Title: Study of Cervical Lesions among Women Workers in a Tertiary Care Hospital
Authors: Dr Nanda J. Patil, Dr Sujata R. Kanetkar, Dr Rashmi L. Sonawane, Dr Malika Mehta
DOI: https://dx.doi.org/10.18535/jmscr/v6i3.83
Abstract
Cervical cancer is the most common cancer among the women worldwide. It has a very long precancerous period which provides a considerable time to detect and treat it. Certain strains of Human Papilloma Virus (HPV) infections which is a common sexually transmitted infection is the primary cause of cervical cancer. Cofactors like other infections, immunocompromised status and tobacco use also play role in progression to frank cancer. The present study was carried out to screen precancerous and cancerous lesions of cervix in women working in tertiary care hospital.
Aims and Objective: To study cervical lesions using Pap smears among women workers in a tertiary care hospital and analysis of results of Pap Smears studies in two months period. (February 2017-march 2017).
Material and Methods: 101 Pap smears were collected among working women in age group of 25-55 years in our hospital in the month of February 2017 and March 2017 and the smears were evaluated according to Bethesda 2014 Guidelines.
Result: The study included 101 cases out of which 54(53.46%) were inflammatory smears, 11 (10.89%) out of 54 smears revealed reactive atypia, 33 smears (32.67%) revealed no significant pathology. Low Grade Squamous Intraepithelial Lesion (LSIL) was seen in 9 (8.9%) cases while 5 smears (4.95%) were inadequate. Amongst these HPV cytopathic effect was seen in 4 cases of LSIL and 2 cases of inflammatory smears. These cases underwent colposcopic examination and will be followed up for six months.
Conclusion: Screening of asymptomatic women workers has yielded significant information. Earlier detection of HPV cytopathic effect and LSIL can offer prompt treatment and cure at the precancerous stage.
Keywords: Cervical Pap smears, Screening test, Precancerous lesions.
References
- Nobbenhuis M., Walboomers J., Helmerhorsty T.,Rozendaal L.,Remmink A.,Risse E.,van der Linden H., Voorhost F.,Kenemans P & Meijer C.Relation of HPV status to cervical lesions and consequence for cervical screening:A prospective study .Lancet.1999,354.20-25.
- Walboomers J.,Jacob M., Manos M., Bosch F.,Kummer J.,Shah K., Snijiders P., Peto J.,Meijer C and Munoz N.Human Papilloma Virus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999,189. 12-19 .
- Munoz N., Bosch F., de San Jose S., Herrero R.,Castellsague X.,Shah K., et al. Epidemiologic classification of Human Papilloma Virus types associated with cervical cancer. N Engl J. Med.2003,348.518-527.
- Burrow OA, Howell LP, Hinricks S, Richard O, Cytomorphological features in the diagnosis of Human Papilloma Virus infection of uterine cervix. Acta Cytol 1990;34:737-738.
- Tanaka H, Chua KL, Lindh E, Hjerpe A. Patients with various types of Human Papilloma Virus covariation and diagnostic relevance of cytological findings in Papanicolaou smears. Cytopathol 1993,4:273-283.
- Bamanikar S.A, Baravkar D.S, Chandanwale S.S et al. Study of cervical Pap smears in a tertiary hospital. Indian Medical Gazette 2014:250-254.
- Gurjar P, Patil N, Bonde V. Detection of Human Papilloma Virus in cervical Pap smears and with polymerase chain reaction technique in the rural area of Western Maharashtra, India. Int J Reprod Contracept Obstet Gynecol. 2016 ;5(8):2648-2651.
- Pradhan B, PradhanS.B., Mital V.P.- Correlation of Pap smear findings with clinical findings and cervical biopsy .Kathmandu University Medical Journal; 2007:5; 4( 20):461-467.
- Ranabhat , S. K., Shrestha, R., Tiwari, M._ Analysis of abnormal epithelial lesions in cervical pap smears in Mid-Western Nepal. Journal of Pathology of Nepal 2011;1,30-33.
- Verma A,Verma S, Vashist S et al. A study on cervical cancer screening in symptomatic women using Pap smear in a tertiary care hospital in rural area of Himachal Pradesh , India Middle East Fertility Society Journal;2017;22 (1):39-42.
- Remzi Atilgan, Aygen Celik, Abdullah Boztoson, Erdin Ilter, Tulin Yalta- Resat Ozercan. Evaluation of cervical cytological abnormalities in Turkish population. Indian J Pathol Micrbiol; 2012 55(1),52-55.
- Turkish Cervical Cancer And Cervical Cytology Research Group: Prevalance of cervical cytological abnormalities in Turkey. Int J Gynaecol Obstet 2009; 106:206-209.
- Ghaith J.E.,Rizwana B.S.- Rate of opportunistic Pap smears screening and patterns of epithelial cell abnormality in Pap smears in Ajman, United Arab Emirates. Sultan Qaboos Univ Med J 2012;12(4):474-478.