Introduction: Menstrual disturbances usually accompany clinical alteration in thyroid function and every clinician would have encountered altered menstrual pattern among women suffering from Thyroid disorder. A high serum Prolactin level can disturb the follicular maturation and corpus Luteum function, and lead to inhibition of normal pulsatile secretion of gonadotrophin releasing hormone in the hypothalamus resulting in anovulation.

Aim: To assess the Hyperprolactinemia and Thyroid disorder among patient with Abnormal Uterine Bleeding.

Method: A Hospital based cross-sectional, observational study was conducted in 150 patients in the department of gynaecology OPD in collaboration with department of Biochemistry and Endocrinology, IGIMS, Patna. The study lasts from May 2016 to October 2017. The patients who presented with abnormal uterine bleeding in age group of 15 -45 years in the out-patient department were recruited in the study after normal USG of Uterus and adnexa. Serum Prolactin and TSH, T3, T4 estimation and CBC, BT and CT were also done.

Result: In present study majority of patients were in the age group between 36-45 years and most of patient were multiparous (81.33%). Heavy menstrual bleeding (36%) was the most common symptom among AUB followed by Frequent menstruation (30%). Thyroid disorder (40.00%) and hyperprolactinemia (14.00%) was responsible for menstrual disturbances found in patient of AUB. Thyroid disorder and serum Prolactin both were responsible for AUB in (9.33%).

Conclusion: In our Study, 40.00% of cases had increased TSH, 14.00% had Increased Prolactin and 9.33% had both raised TSH and Prolactin associated with AUBand 36.67% were found to have no association with AUB.

Keyword: AUB, Prolactin, Thyroid function test.

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Dr Dipali Prasad

Assistant Professor, Department of Obstetrics and Gynaecology

Indira Gandhi Institute of Medical Science, Patna