Background: Fertility regulation has acquired great importance in the field of human reproduction. The use of synthetic progestogens has completely revolutionized the field of contraception as these offers a reliable, safe, easy and reversible method of contraception. We aim to examine the lipid and lipoprotein changes in women taking low dose oral contraceptives.

Aim: To study the effect of oral contraceptives on Lipid profile of Premenopausal Indian women.

Material and Method: This hospital-based study was conducted on 100 pre-menopausal women, 50 as control and 50 as cases, age and gender matched. Blood Sample were taken in plain vial and lipid profile was done on each sample on Semiautoanalyzer. Results were collected and analyses statically.

Result: The mean value of serum cholesterol in cases group and control group were 193.48± 14.49 mg% and 184.46± 13.58 mg% respectively with  p value of <0.001 serum triglyceride is 91.16±11.04 mg% and 85.26±11.03 mg% respectively with  p value of <0.01. Mean value of HDL in cases and control were 44.70±5.12 mg% and 46.62±5.11 mg% with p value of >0.05.This shows that serum total cholesterol and serum triglyceride shows statically significant association while serum HDL shows no association.

Conclusion: Tablet Mala- D causes very significant increase in total serum cholesterol and LDL cholesterol, triglycerides while there was no significant change in HDL cholesterol levels and it is almost 100 % effective in preventing pregnancy.

Keywords: Mala –D, Serum Cholesterol, Serum Triglyceride, HDL.

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Dr Tejinder Singh

Department of Biochemistry,

Government Medical College, Amritsar