Objectives: To assess the effects of hypothyroidism on renal physiology.

Methodology: The study was conducted on subjects in the age group of 20-65 years. Subjects were divided into two subgroups: Euthyroid and hypothyroid on the basis of thyroid function tests. Bodyweight and height was taken. Data was subjected to one way analyses of variance. In all the cases, means are used as units of analyses. Individual values for each subject were taken as one replicate. A P-value of less than 0.05 was considered statistically significant.

Conclusion: This study shows that there is significant increase in creatinine and uric acid levels in hypothyroid patients as compared to euthyroid subjects.

Keywords: Hypothyroidism, renal function tests.

1. Larry J Jameson and Anthony P Weetman. Disorders of the Thyroid gland.In: Harrison`s Principles of Internal Medicine Mc Graw-Hill,(2005).
2. Braunlich H. Thyroid hormones influen-cing renal electrolyte excretion in saline loaded rats of different ages. Physiologia Bohemoslovaca 1984; 33: 303–308.
3. Kumar V and Prasad R. Molecular basis of renal  handling of calcium in response to thyroid hormone status of rat. Biochim Biophys Acta 1998; 1586: 331–
4. Kaptein EM, Quion Verde H and Massry SG. Hemodynamic effects of thyroid hormone. Contributions to Nephrology 1984; 41: 151–159.
5. Den Hollander JG, Wulkan RW, Mantel MJ and Berghout A. Correlation between severity of thyroid dysfunction and renal function. Clinical Endocrinology 2005; 62(4): 423- 7.
6. Li Bok, Fekete NF and  Harsing L. Renal  structural and functional changes  and  sodium  balance  in  hypothyroid  Acta Med. Acad. Sci. Hung 1982; 39: 219-225.
7. Vargas F, Moreno JM, RodríguezGómez I,Wangensteen R, Osuna A, Alvarez-Guerra M and García-Estañ J. Vascular and renal function in experimental thyroid disorders. European Journal of Endocrinology 2006; 154: 197–212.
8. Patel YC, Alford FP and Burger HG. The 24 hour plasma thyrotropin profile.Clin Sci 1972; 43: 71-77.
9. Sterling K and Lazarus JH. The thyroid and its control. Annu Rev Physiol 1977; 39: 349-71.
10. Lin CC, Chen TW, Ng YY, Chou YH and Yang WC. Thyroid dysfunction and nodular  goiter in hemodialysis and peritoneal dialysis patients. Perit Dial Int 1998; 18(5): 516-21.
11. Nakahama H, Sakaguchi K and Horita Y et al. Treatment of severe hypothyroidism reduced serum creatinine levels in two chronic renal failure patients. Nephron 2001; 88(3): 264-7.
12. Camacho GD, Ceballos LT, Angelin BP, Moreno JAR, Nieto MLH and Gonzalez JR. Renal failure  and  acquired  Pedia Nephrol 2003; 18(3): 290-92.
13. Giordano N, Santacroce C, Mattii G, Geraci S, Amendola A and Gennari C. Hyperuricemia and gout in thyroid endocrine disorders. Clin Exp Rheumatol 2001; 19(6): 661-5.
14. Sarika Arora, Ranjna Chawla, Devika Tayal, Vinod K Gupta, Jagdeep S Sohi and Mallika V. Biochemical markers of  liver  and  kidney function  are  influenced by thyroid function a case-controlled follow up study in Indian hypothyroid subjects. Indian Journal of Clinical Biochemistry 2009; 24 (4): 370-374.
15. Kreisman SH and Hennessey JV. Consistent reversible elevations of serum creatinine levels in severe hypothyroidism. Archives of Internal Medicine 1999; 159: 79–82.
16. Saini V, Yadav A, Arora MK, Arora S, Singh R and Bhattacharjee J. Correlation of creatinine with TSH levels in overt hypothyroidism: A requirement for monitoring of renal function in hypothyroid patients?Clin Biochem. 2012; 45: 212–4.

Dr Meenakshi Sharma

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