Abstract
A Paraquat is a bipyridyl compound used as a herbicide in agriculture. The ingestion of this compound, even in minimal quantity is detrimental and has fatal consequences. In this case series we study 10 cases of Paraquat compound self-ingestion, its clinical course and the potential therapies that can be harnessed in the future for better outcomes.
Keywords: Paraquat poisoning, supportive treatment, prognosis, mortality.
References
- Eddleston M. Patterns and problems of deliberate self-poisoning in the developing world. QJM. 2000;93:715–31.
- Gazette of India, Union ministry for Agriculture and Farmers welfare. December 15, 2016
- Castello PR, Drechsel DA, Patel M. Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain. J BiolChem2007;282: 14186–93.
- Wilks MF, Tomenson JA, Fernando R, Ariyananda PL, Berry DJ, Buckley NA, Gawarammana IB, Jayamanne S, Gunnell D, Dawson A. Formulation changes and time trends in outcome following paraquat ingestion in Sri Lanka. ClinToxicol (Phila) 2011;49:21–8.
- Singh, P. Bambery, D. Chaudhry, G. Makharia, N. Kakkar, and D. Singh, “Fatal paraquat poisoning: report of two cases,” Journal of Association of Physicians of India, vol. 47, no. 8, pp. 831–832, 1999.
- S. Sandhu, A. Dhiman, R. Mahajan, and P. Sandhu, “Outcome of paraquat poisoning—a five year study,” Indian Journal of Nephrology, vol. 13, pp. 64–68, 2003.
- Agarwal, R. Srinivas, A. N. Aggarwal, and D. Gupta, “Experience with paraquat poisoning in a respiratory intensive care unit in North India,” Singapore Medical Journal, vol. 47, no. 12, pp. 1033–1037, 2006.
- Yoon S-C. Clinical Outcome of Paraquat Poisoning. The Korean Journal of Internal Medicine. 2009;24(2):93-94. doi:10.3904/kjim.2009.24.2.93.
- Impact of paraquat regulation on suicide in South Korea. Cha ES, Chang SS,, Gunnell D, Eddleston M, Khang YH, Lee WJ International journal of Epidemiology, Vol 45, Issue 2, 1 April 2016, Pages 470 479, https://doi.org/10.1093/ije/dyv304
- Woojae Myung, Geung-HeeLee, Hong-Hee Won,, Maurizio Fava David Mischoulon, Maren Nyer,Doh Kwan Kim, Jung-YoonHeo, Hong Jin Jeon. Paraquat Prohibition and Change in the Suicide Rate and Methods in South Korea. PLOS ONE | DOI:10.1371/journal.pone.0128980 June 2, 2015
Corresponding Author
Devasena Srinivasan
Department of Medicine, Sri Ramachandra Medical College and Research Institute,
1,Ramachandra nagar, Porur, Chennai 600116 Tamil Nadu