Background: Diabetes is almost everywhere a most common growing health issue in the world and is now emerging as an epidemic world over. currently, so much of  importance is being paid to the natural  products study  as potential  antidiabetics. The study  of  plants  which  possess  Antidiabetic  activity may give a  new  idea  in treatment  approaches of  Diabetes mellitus(DM).

Objective: The  present  research  study  was  aimed  to  evaluate  the Hypoglycemic  action  of  Gymnema Sylvestre (G. sylvestre) plant leaf methanolic extract (GSLME)  in  streptozocin ‑ induced  diabetic  albino rat  model.

Methods: Albino rats with a weight of 150- 200 grams were weighed & were grouped into 6 equal groups taking 6 rats in each. Group A served as control (normal), Group B as diabetic control, received streptozocin (60mg/kg.b.w.) after overnight fasting. Group C ,D & E  was  received streptozocin+ GSLME  suspension  at 100 ,200 & 300 mg/kgdoses orally  respectively, Group E  was  given  streptozocin + standard drug (Glibenclamide 5mg/kg.b.w.) suspension   for 30 days orally &  the  GSLME  effect  on blood sugar(BS)  was measured with  glucometer  at  regular intervals. At the end of this research study samples of   blood were collected from all rats for biochemical estimation of  BS.

Results: This  present  research study  has  revealed  that GSLME  has  Hypoglycemic  effect  against  streptozocin  induced  diabetic albino rats  on  i.p. streptozocin  injection at 60mg/kg.b.w. & confirms that on  i.p. streptozocin  injection  causes  a significant raise in fasting blood sugar (FBS) in untreated albino rats  when compared to control group. Diabetic  rats treatment with  GSLME  for  30 days  caused  a dose dependent  fall  in FBS  levels. Diabetic  rats treated with  Glibenclamide also  showed  a  significant(P < 0.00)  fall  in  FBS  levels after  30 days of  treatment.

Conclusion: It is concluded that GSLME   has shown significant Hypoglycemic action at 100, 200 & 300 mg/kg. b.w. doses in  alloxan monohydrate   induced  diabetic  albino  rats.

Keywords:  GSLME, Glibenclamide, Hypoglycemic,albino rats, BS.

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Dr. Chakrapani Cheekavolu

Assistant Professor, Department of Pharmacology, Kerala Medical College and Hospital,

Mangode, Palakkad, Kerala, India,

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