Title: Relation between Primary Open Angle Glaucoma and Neurodegenerative Diseases-A Case Control Study
Authors: Dr Padmasree K. M., Dr Jacob George, Dr Elizabeth John
DOI: https://dx.doi.org/10.18535/jmscr/v5i12.49
Abstract
Introduction
Glaucoma is nowadays considered as a disease of optic nerve where in it is susceptible to damage from many factors. The nerve is susceptible to the existing IOP, or `the damage can be due to IOP independent mechanisms. The damaging IOP can be much lower than the statistical normal range .The seemingly non IOP dependent damage seen in some patients even after control of the IOP factor, made us think about other alternative pathogenesis factors and this concept of Normal Tension Glaucoma has influenced our understanding of glaucoma, resulting in elimination of IOP from the diagnostic criteria of POAG.
Neurodegenerative (NDD) disease was accidentally discovered to have an association with POAG when Chandra et al1 found an increased incidence of POAG in the death registry record of people with dementia. The association was seen consistently in a few subsequent observational studies. Research also suggests common pathogenesis and terminal cellular events (apoptosis) in both.
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