Background: Thyroid hormone abnormalities are frequently encountered in patients with sepsis, sepsis is important cause of death in developing countries. The aim of  study is to analyze thyroid profile in sepsis patients at admission and evaluate the prognostic role of thyroid dysfunction in sepsis patients.

Method:  In prospective observational study, thyroid hormone levels (FT3, FT4, TSH) measured in 75 in-patients with sepsis . Serum thyroid level measured by chemiluminescent assay at the time of admission. Sepsis patients further divided into survivors and non- survivors.

Observation and Results: Thyroid profile was assessed in 75 sepsis inpatients, low FT3 (56%) was the commonest abnormality observed, followed by low FT4 (10.67%) and high TSH (10.67%) followed by low TSH (8%).

-Non survivors have low mean FT3 (1.56 ± 0.77) than survivors (2.31 ± 0.65) which was statistically significant (p <0.0001). Significant positive correlation observed between serum FT3 and serum albumin (p=0.002, r=0.36)

Conclusion:  low level of FT3 has positive correlation with decrease survival in sepsis patients. FT3 may be used as predictor of mortality. Serum FT3 and serum albumin have positive correlation.

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M. Patidar

RMO, Department of Medicine

N.S.C.B Medical College Jabalpur