Abstract
Introduction: the pancreas is a glandular organ of dual composition with both exocrine and endocrine components. Tumors of exocrine pancreases are rare with more than 95% being malignant.
Methods & Materials: this is a retrospective clinico-histopathological study of 89 cases registered in our center from July 2005 to Jan 2015. The details of patients were retrieved from patients’ files. Information retrieved included socio-demographic data, clinical presentation, anatomical site, gross appearance, tumor stage, histopathological type and grade, presence of metastasis.
Results:during the study period, a total of 89 malignancies were registered. Of these, 48 (53.9%) were histopathologically confirmed pancreatic cancer. The diagnosis in the remaining 41 patients was based on clinical and radiological basis.Male to female ratio of 1.6:1. The age ranged from 35 to 90 years with a median age of 63 years. Fifty seven patients (64%) presented with abdominal pain, 41 patients (46%) were jaundiced. Thehead was the most frequent site for pancreatic tumor in 48 (54%) cases followed by tail, body. Adenocarcinoma was the most common histopathological tumor in 43(90%) patients. Thirty(33.7%) patients were presented in locally advanced stages and 54(60.6 %) patients had metastasis.
Conclusion: Our study was limited by being a retrospective, a relatively small number of patients and representing the experience of a single cancer center so, larger scale prospective studies are recommended to study the clinicodemografic character of this disease in the country.
Keywords: Pancreatic Cancer, clinical, demographic, retrospective.
References
- Rosai J. Pancreas and ampullary region. In: Rosai and Ackerman’s Surgical Pathology. 10th ed. Missouri: Elsevier Mosby: 2011.
- Hollingsworth MA. Proteins expressed by pancreatic duct cells and their relatives. Ann N Y AcadSci 1999; 880:38-49.
- Hruban RH, Donahue DL. The Pancreas. In: Kumar, Abbas, Fasuto, Aster, editors. Robbins and Cotran Pathologic Basis of Disease. 8th ed. Philadelphia: Elsevier Saunders; 2010. p. 891-903.
- Warshaw AL, Castillo CF. Pancreatic carcinoma. N Engl J Med1992; 326:455-65.
- Ghadirian P, Lynch HT, Krewski D. Epidemiology of pancreatic cancer: an overview. Cancer Detect Prev 2003; 27: 87-93.
- Lynch HT, Smyrk T, Kern SE, et al. Familial pancreatic cancer: a review. SeminOncol 1996; 23:251-75.
- Everhart J, Wright D. Diabetes mellitus as a risk factor for pancreatic cancer: a meta-analysis. JAMA 1995; 273:1605-9.
- Dhir V, Mohandas K. Epidemiology of digestive tract cancers in India IV. Gall bladder and pancreas. Indian J Gastroenterol1999; 18(1): 24-8.
- Cancer Facts & Figures. American Cancer Society. Available at http://www.cancer.org/Research/CancerFactsFigures/index. Accessed: October 8, 2014.
- Gold E.B., and Goldin B. Epidemiology of and risk factors for pancreatic cancer. SurgOncolClin North Am 1998; 7:67-91.
- Howlader N, Noone AM, Krapcho M, Neyman N, AminouR, Waldron W, et al, editors. SEER Cancer Statistics Review1975-2008 National Cancer Institute SEER Cancer StatisticsReview 1975-2008 National Cancer Institute. Bethesda (MD):National Cancer Institute; 2011.
- Doherty GM, Way LW. Pancreas. In: Way LW, Doherty GM, editors. Current surgical diagnosis and treatment. New York:Lange Medical Books; 2003. pp. 602–12.
- Sonnefeld T, Nyberg B, Perbeck L. The effect of palliative biliodigestive operations for unresectable pancreatic carcinoma.J Acta Chir Scand Suppl. 1986; 530:47–50.
- Shi C, Hruban RH, Klein AP. Familial pancreatic cancer. Arch Pathol Lab Med 2009; 133: 365–74.
- Cowgill SM, Muscarella P. The genetics of pancreatic cancer. Am J Surg 2003; 186: 279-86.
- Li D, Jiao L. Molecular epidemiology of pancreatic cancer. Int J Gastrointest Cancer 2003; 33:3-14.
- Kumar NV. Clinical study of carcinoma pancreas [dissertation]. Mangalore: Rajiv Gandhi Univ.; 2007.
- American Cancer Society. Cancer Facts & Figures 2011. USA:American Cancer Society, Inc.: 2011. p. 1-55.
Corresponding Author
Ramadan Elamyal
Department of Surgery, Misurata Cancer Center, Misurata, Libya
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v5i12.19
