Abstract
Background: Pancytopenia is one of the most common haematological disorders, which is characterized by decrease in all the formed elements of blood. Pancytopenia occurs either due to certain primary conditions affecting the bone marrow or involvement of bone marrow secondarily by various systemic pathological process.
Objectives: The main objectives of the study are to evaluate the incidence and pattern of pancytopenia by analyzing the haematological data available during one year in the central laboratory of a tertiary care hospital in Navi Mumbai and to correlate the haematological findings with bone marrow findings.
Methods: The present prospective study, consists of an analysis of haematological data over a period of one year and analysing the incidence and pattern of pancytopenia and to correlate the haematological findings with bone marrow findings.
Results: In this study, 100 cases of Pancytopenia are diagnosed with an incidence of 0.47%. Bone marrow findings are available in only 15% cases of pancytopenia, and maximum incidence of pancytopenia, 5 cases (33.3%) is associated with chronic liver disease, followed by association with megaloblastic anaemia, 2 (13.3%) cases. In rest of the cases, definitive diagnosis of pancytopenia is not available, though the patients are being treated for various clinical conditions.
Conclusion: The highest incidence of pancytopenia is found in age group of 40-70 years. Bone marrow findings confirmed the diagnosis in 15% cases, showing Dysmegakaryopoiesis maximum incidence of cases associated with erythroid hyperplasia with megaloblastoid changes and chronic liver disease accounted in 21 cases of pancytopenia.
Keywords: Pancytopenia, Megaloblastoid change, Dysmegakaryopoiesis
References
- Guinan EC, Shimamura A. Wintrobe's Clinical Hematology. In: Greer JP, Foerster J, Lukens JN, RodgersGM, Paraskevas F, Glader B, editors. Acquired and inherited aplastic anemia syndromes. 11th ed.Philadelphia: Lippincott Williams and Wilkins; 2004. pp. 1397–419.
- PhurailatpamMadhubala Devi, Rajesh Singh Laishram, PhurailatpamSarojkumar Sharma, et al. Clinico-hematological Profile of Pancytopenia in Manipur, India. Kuwait Medical Jou. 2008, 40(3): 221-224
- Khunger JM, Arulselvi S, Sharma U, Ranga S, Talib VH. Pancytopenia: a clinicohaematological study of 200 cases. Indian J Pathol Microbiol 2002; 45:375–9.
- Rajesh Para, Shailaja Para. Pancytopenia - a study of 58 cases.Journal of Evolution of Medical and Dental Sciences 2013; Vol. 2, Issue 45, November 11; Page: 8724-8728.
- Khodke K, Marwah S, Buxi G, Yadav RB, Chaturvedi NK. Bone marrow examination in cases of pancytopenia. J Indian AcadClinMed 2001; 2: 55–9.
- Tilak V, Jain R. Pancytopenia: a clinico-hematologic analysis of 77 cases. Indian J PatholMicrobiol 1999; 42: 399–404.
- Singh P, Mohanty RC, Mohanty R, Alam S. Pancytopenia: a clinico hematological study. Int J Res Med Sci 2016;4:4339-48.
- Sheetal Mahesh Sale etal.Clinical correlation of pancytopenia with bone marrow study in a tertiary. Indian Journal of Pathology and Oncology, April-June 2016;3(2);247-254.
- Mahasweta Mallik, Richa Bhartiya, Sujata Mallick, Rashmi Singh, Manish Kumar, Ran Vijoy Narayan Singh. Pancytopenia – a study of clinico-haematological profile in adults with its bone-marrow co-relation in a tertiary hospital of bihar. International Journal of Contemporary Medical Research 2016;3(6):1689-1691.
- Pathak R, Jha A, Sayami G. Bone Marrow Examination in Cases of Pancytopenia. J Nepal Med Assoc 2008;47(169):12-7.
- Sweta, Barik S, Chandoke, RK, Verma AK.A prospective clinico-hematological study in 100 cases of pancytopenia in capital city of India. J Appl Hematol 2014;5:45-50.
- Gayathri BN, Rao KS. Pancytopenia: A clinicohematological study. J Lab Physicians; 2011;3:15-20.
- Deepak B. Kumar, A. R. Raghupathi. Clinicohematologic analysis of pancyto-penia: Study in a tertiary care centre. Journal of Basic and applied Pathology. Vol 5, Issue 1;March 2012; Pages 19–21
- Khudair Abbas Al-Khalisi, Azher Sebieh Al-Zubaidy, Majid Rhaima. The Iraqi postgraduate Medical Journal. vol.10, no.4, 2011; 141-148.
- Dr Deepa Tekwani et al. Clinico-Haematological Analysis of Pancytopenia in Adults. JMSCR; Volume 05 Issue 03 March 2017; 19020-19026
- Kumar R, Kalra SP, Kumar H, Anand AC, Madan H. Pancytopenia: a six year study. J Assoc Physicians India, 2001; 49: 1078–81.
- Bhaskar B Thakkar, Ukti N Bhavsar, N J Trivedi, A S Agnihotri.A study of pancytopenia in adult patientsmore than 12 years of age in north-west regionof Saurashtra. National Journal of Medical Research. Volume 3; issue 1; Jan – March 2013; 48-52.
- Savage DG, Allen RH, Gangaidzo IT et al. Pancytopenia in Zimbabwe. Am J Med Sci 1999; 317: 22–3. Journal of Evolution of Medical and Dental Sciences 2013; Vol. 2, Issue 45, November 11; Page: 8724-8728
- Pine M, Walter AW. Pancytopenia in hospitalized children: five-year review. J Pediatr Hematol Oncol 2010; 32: e192–4
Corresponding Author
Kalyani Mahore
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