India has widespread prevalence of diabetes and hypovitaminosis D. This study was conducted to evaluate the relationship between serum 25-hydroxyvitamin D [25(OH)D] and glycemic control in patients with type 2 Diabetes Mellitus [T2DM]. 157 subjects (100 T2DM; 57 controls) were sampled and their 25(OH)D, FBG, PPBG and HbA1c were measured. Additionally, T2DM patients were classified into controlled diabetic and uncontrolled diabetic group based on glycemic control (HbA1c level <7% or ≥ 7%). Data analysis was done by t-test for continuous measures and chi-square test for categorical measures. Mean vitamin D level was significantly lower in the diabetic compared to Control group (15.1 ± 5.18 v/s 22.66 ± 5.49 ng/ml, P<0.01). 82% diabetics and 33.4% controls were Vitamin D “deficient” (<20ng/ml). 18% diabetics and 56.1% Controls were Vitamin D “insufficient” (20-29 ng/ml). FBS (96.8±16.3 v/s 146.5±55.2, P<0.01), PPBS (125.3±22.9 v/s 210.5±76.6, P<0.01), HbA1c (8.1 ± 2.2 % v/s 5.6 ± 0.2 %, P<0.01) and calcium (9.21±.89 v/s 7.89±.70, P =0.04) were also found to be statistically different between controls and diabetics. Mean vitamin D level in the controlled diabetic v/s uncontrolled diabetic group was (14.95±4.77 v/s 15.15±5.59 ng/ml, P =1.00). Thus, Vitamin D deficiency may be an etiological factor for the development of T2DM, but may not have a role in the glycemic control in T2DM

Keywords: Type 2 diabetes mellitus; Vitamin D; Glycemic control; Glycated haemoglobin

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Fahmiya Leena Yacoob

Aspira Pathlab and Diagnostics Ltd., Mumbai, India

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