Abstract
Background: Essential hypertension may have a cause but our knowledge is not enough to recognize it. The sympathetic nervous system helps to control circulation. Increased incidence of tachycardia, arrhythmias in hypertension, suggests abnormality in sympathetic autonomic system. So the present study was aimed to study blood pressure and heart rate responses during sympathetic stress like ‘cold pressor test’ (CPT) and ‘sustained hand grip test’ (SHG) in stage 1 essential hypertensive subjects.
Study Setting and Design: Analytical, cross-sectional, comparative study in the Department of Physiology, B J medical college and Sassoon hospital, Pune.
Materials and Methods: 50 newly diagnosed essential hypertensive male subjects in the age group of 35 -50 years having stage 1 hypertension according to JNC 7 criteria were selected in study group. Healthy age and gender matched, 50 normotensive subjects were included in control group. After informed consent, blood pressure and heart rate responses were measured during sympathetic stress like ‘cold pressor test’ (CPT) and ‘sustained hand grip test’ (SHG) in the study group and the control group. Statistical analysis: Comparisons were performed using ‘z-test’ in the two groups.
Results: During cold pressor test and sustained hand grip test blood pressure and heart rate responses were significantly increased in stage 1 essential hypertensive subjects as compared to normotensive subjects. (p<0.05)
Conclusion: The sympathetic autonomic activity is increased in stage 1essential hypertensive subjects as compared to normotensive subjects.
Keywords: Hypertension, sympathetic autonomic function, cold pressor test (CPT), sustained hand grip test (SHG).
References
- Carthy ER. Autonomic dysfunction in essential hypertension: A systematic review. Ann Med Surg. 2014; 3(1): 2-7.
- Reddy KS.Regional case studies-India. Nestle NutrWorkspSerPediatr Program. 2009; 63: 15-24; discussion 41-16, 259-268.
- Dustan HP, Tarazi RC, Bravo EL. Physiologic characteristics of hypertension. Am J Med. 1972; 52(5): 610–22.
- Legrady P, Bajcsi D, Lengyel C, Varkonyi T, Fejes I, Kempler P, et al . Investigation of cardiac autonomic and peripheral sensory neuropathy in diabetic and nondiabetic patients with hypertension. Clinical and Experimental Hypertension. 2013; 35(6): 465-69.
- Hayreh SS, Servais GE, Virdi PS. Fundus lesions in malignant hypertension: V. Hypertensive optic neuropathy. Ophthalmo-logy. 1986; 93(1): 74-87.
- Branch R, Ali S, Ring C, Winer J, Martin U. Evidence of peripheral neuropathy in unmedicatedhypertensives. Br J ClinPharmacol. 2010; 70(2): 293
- Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo Jr, et al. National heart, lung, and blood institute joint national committee on prevention, detection, evaluation, and treatment of high blood pressure; national high blood pressure education program coordinating committee. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7, 2003; 2560-72.
- Reddy K, Shah B, Varghese C, Ramadoss A. Responding to the threat of chronic diseases in India. Lancet. 2005. 366: 1744-9.
- Manjunath ML, Babu G. Comparative study of cardiovascular response in trained and untrained volleyball and basketball players. Int J Appl Biol Pharm. 2011; 2(2): 354-60.
- Victor RG, Leimbach WN, Seals DR, Wallin BG, Mark AL. Effects of the cold pressor test on muscle sympathetic nerve activity in humans. Hypertension. 1987; 9(5): 429-36.
- Pal GK, Pal P. Textbook of practical physiology.3rd ed. Hyderabad: Universities Press (India) Pvt Ltd; 2010. p 282-90.
- Hines EA, Brown GE. The cold pressor test for measuring the reactivity of the blood pressure: data concerning 571 normal and hypertensive subjects. Am Heart J. 1936; 11:1–9.
- Millar PJ, Bray SR, McGowan CL, MacDonald MJ, McCartney N. Effects of isometric handgrip training among people medicated for hypertension: a multilevel analysis. Blood Pressure Monitoring. 2007; 12(5): 307-14.
- Mostoufi Moab S, Widmaier EJ, Cornett JA, Gray K, Sinoway LI. Forearm training reduces the exercise pressor reflex during ischemic rhythmic handgrip. J Appl Physiol. 1998; 84(1): 277-83.
- Hietanen E. Cardiovascular responses to static exercise. Scand J Work Environ Health. 1984; 10: 397-402.
- Julius S, Conway J. Hemodynamic studies in patients with borderline blood pressure elevation. Circulation.1968; 38: 282-88.
- Korner PI. Essential hypertension and its causes: neural and nonneural mechanisms [Internet]. New York: Oxford University Press; 2007. Available from: www.hbprca.com.au/wp-content/uploads/paulkorner.pdf
- Legrady P, Bajcsi D, Lengyel C, Varkonyi T, Fejes I, Kempler P, et al .Investigation of cardiac autonomic and peripheral sensory neuropathy in diabetic and nondiabetic patients with hypertension. Clinical and Experimental Hypertension. 2013; 35(6): 465-69.
Corresponding Author
Talele Pallavi
Tutor, Dept of Physiology,B. J. Government Medical College, Pune, India.
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v5i10.170
