Abstract
In the present study prescribing pattern of various drugs prescribed in Acute Coronary Syndromes (ACS) was studied. It was a retrospective, observational study in the Department of Pharmacology and Medicine from June to May 2017. The data from Record Department from 2011 to 2015. Prescribing patterns of various drugs prescribed in ACS were analyzed. 600 complete records of patients admitted for ACS were included in the study, of which 483 (80.5%) were of male patients and 117 (19.5%) were of female patients. Hypertension (39%) and diabetes (6.8%) were the most common co-morbid conditions associated with ACS. The most commonly prescribed drug classes for main indications in Acute Coronary Syndrome were anti-platelet drugs 600 (100%) followed by antihypertensives (96.16%) and antihyperlipidemics (91.16%). Extensive polypharmacy (9.68 drugs per prescription) was noticed in the prescriptions. The prescribing pattern can be improved by reducing the number of drugs per prescription. Many drugs were prescribed by generic name (61%). The economic burden of the patients can be reduced by prescribing more generic drugs.
Keywords: Prescription pattern, Acute coronary syndrome, Observational Study, Polypharmacy.
References
- Lloyd-Jones D, Adams R, Carnethon M, et al; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics—2009 update. a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee Circulation. 2009 Jan 27;119(3):480-486. Epub 2008 Dec 15
- (Nichols M, Townsend N, Scarborough P, et al. Cardiovascular disease in Europe 2014: epidemiological update. Eur Heart J 2014;35:2929. 10.1093/eurheartj/ehu378
- Reddy KS . Cardiovascular disease in non-Western countries. N Engl J Med. 2004 Jun 10; 350(24):2438-40.
- Okrainec K, Banerjee DK, Eisenberg MJ. Acute Coronary Syndromein the developing world. Am Heart J. 2004 Jul; 148(1):7-15.
- Enas EA, Kannan S. How to beat the heart disease epidemic among South Asians. A prevention and management guide for Asian Indians and their doctors. Downers Grove: Advanced Heart Lipid Clinic USA, 2007. Indian Heart J 2008; 60: 161–175.
- Acute Coronary Syndromes: Diagnosis and Management, Part I Amit Kumar, MD, and Christopher P. Cannon, MD, Mayo Clin Proc. • October 2009;84(10):917-938
- Balady GJ, Williams MA, Ades PA, Bittner V, Comoss P, Foody JAM, et al. Core components of cardiac rehabilitation/secondary prevention programs. Circulation. 2007; 115: 2675–2682.
- Beaglehole R, Epping-Jordan A, Patel V, Chopra M, Ebrahim S, Kidd M, Haines A. Improving the prevention and management of chronic disease in low-income and middle-income countries: a priority for primary health care. Lancet. 2008; 372: 940–949.
- De Wilde S, Carey IM, Richards N, Whincup PH, Cook DG. Trends in secondary prevention of ischemic heart disease in the UK 1994–2005: use of individual and combination treatment. Heart. 2008; 94: 83–88.
- Newby LK, LaPointe NMA, Chen AY, Kramer JM, Hammill BG, DeLong ER, et al. Long term adherence to evidence based secondary prevention therapies in coronary artery disease. Circulation. 2006; 113: 203–212.
- Ramsay LE. Bridging the gap between clinical pharmacology and rational drug prescribing. Br J Clin Pharmacol. 1993; 35: 575-576.
- Vries MD, Heluling RH, Hogerzeil HV, Freste DA. Guide to good prescribing. A practical guide W.H.O. 1994.
- Pradhan SC, Shewade DG, Shashindren CH, Bapna IS. Drug utilization studies. National Med J India. 1988; 1: 185-189
- World Health Organization. (1993). How to investigate drug use in health facilities: selected health use indicators. Geneva: 1-87. Available online at http://www.google.co.in/url?sa=t&source=web&cd=2&ved=0CB8QFjAB&url=http%3A%2F%2Farchives.who.int%2Fprduc2004%2Frducd%2FINRUD_2000_CDROM%2FManuals%2FHow%2520to%2520Investigate%2520Drug%2520Use.pdf&rct=j&q=World%20Health%20Organization%2C%20%281993%29%2C%20How%20to%20investigate%20drug%20use%20in%20health%20facilities%3A%20selected%20health%20use%20indicators&ei=GHFbTfSIJY_BccyGza4K&usg=AFQjCNFD8QdnSliahUxtsOs0bNf_L Jplrg&cad=rja (accessed on 15th March, 2015)
- Kamath A, Shanbhag T, Shenoy S, Ramesh S. A retrospective study of the drug prescribing pattern in acute myocardial infarction. Ind J Pharmacol. 2008; 40: S60- S61.
- Tasneem S and Fouzia N. Drug utilization study in ischemic heart diseases associated with diabetes and hypertension. Int J Pharma and Bio Sci. 2010; 1(3): 1-4.
- Jorg M, Giorgio N, Roger D, Christiane G, Felix G, Ferenc F. National survey on prescription of cardiovascular drugs among outpatients with Acute Coronary Syndromein Switzerland. Swiss Med Wkly 2003; 133: 88-92.
- Banerjee S, Kumar V, Ramachandran P, Kamath A. Does the pharmacological management of unstable angina vary with age and gender – a descriptive study. Journal of Clinical and Diagnostic Research. 2010; 4:3150-3157.
- Datta S, Sharma C. Prescribing pattern of antihypertensives in patients having comorbid ischemic heart disease: Study in a tertiary care hospital. Journal of Pharmacy Research. 2010; 3: 2142-2144.
- Sreedevi K, Rao VJ, Fareedullah MD, Vijayakumar S. A study on prescription pattern of statins in cardiovascular disease. Der Pharmacia Lettre, 2011; 3: 393-396.
Corresponding Author
Dr A P Marawar
Department of Pharmacology, Rural Medical College, PIMS (DU), Loni (BK),
Tal- Rahata, Dist- Ahmednagar, Maharashtra, India. Pin code-413736
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v5i10.167
