Title: A Study of Vitamin D Status in Insulin Resistant Type 2 Diabetics in a Tertiary Care Hospital
Authors: Sibasis Bhattacharyya, Mousumi Mukhopadhyay, Jotideb Mukhopadhyay
DOI: https://dx.doi.org/10.18535/jmscr/v5i10.89
Abstract
The aim of this study was to assess vitamin D status in insulin resistant type 2 diabetics in a tertiary care hospital. The study was conducted on thirty newly diagnosed type 2 diabetics. Age and sex matched control population was also taken into consideration. The study was conducted over a period of one year in a region where there is enough exposure to sunlight. The level of plasma 25(OH)D was measured. The level of fasting blood glucose and fasting insulin was also measured. Insulin Resistance was measured using HOMA (Homeostasis Model Assessment Method), where HOMA values greater than 2.6 are suggestive of Insulin Resistance. The mean plasma 25(OH)D level was 15.35 +- 5.1 nmol/l in diabetics, with 87% of case population being vitamin D deficient , whereas mean vitamin D is 25.7 +- 5.6 nmol/l in control population with only 17% control population diabetic. The mean Insulin Resistance is 5.8+-1.9 among Diabetic Population in comparison to HOMA value of 1.4 +-0.7 among controls. There was significant difference of HOMA IR between cases and controls (p =0.006).We found a significant correlation between Vitamin D deficiency and Insulin Resistance. Our results suggest that vitamin D deficiency is prevalent among newly diagnosed Type 2 diabetics even in region where there is adequate exposure to sunlight throughout the year
Key Words: 25(OH)D: 25 Hydroxy Cholecalciferol, HOMA-IR: Homeostasis Model Assessment – Insulin Resistance, T2DM: Type 2 Diabetes Mellitus, ADA: American Diabetic Association, ELISA: Enzyme Linked Immuno Absorbant Assay.
