Title: Study on Serum Magnesium Level in Type 2 Diabetes Mellitus in North Indian Population
Authors: Archana Mishra, Vandana Tiwai, Jyoti E John, Rakesh Kr Shukla , Manish Raj Kulshrestha
DOI: https://dx.doi.org/10.18535/jmscr/v5i10.62
Abstract
Background: Magnesium within the body has been associated with several disease such as Diabetes mellitus. Hypomagnesaemia has been reported to occur at an increased frequency among patients with type 2 diabetes compared with healthy non diabetic subjects.
Methods: 125 patients of Type 2Diabetes Mellitus, who were diagnosed on the basis of WHO criteria, were included in this study and 100 healthy controls were also included. Detailed history and physical examination of all patients were done and all patients underwent laboratory tests for FBS, PPBS, HbA1c, Serum urea, Serum creatinine and magnesium level.
Results: The prevalence of hypomagnesaemia was quite higher in cases (29%) as compared to that of controls (6%)In this study, no statistically significant correlation was found between level of magnesium and age (p=0.063). In present study no statistically significant association was found between level of magnesium and serum creatinine level (p=0.792) and that of level of magnesium and serum urea (p=.481). The mean values of FBS, PPBS, HbA 1C in diabetic cases were found to be higher in cases then the healthy controls and was highly significant Pearson's correlation showed that serum magnesium correlated negatively to FBS (r = −0.225, P < 0.002),PPBS(r=−0.228,P < 0.016) and HbA1C (r = −0.203, P < 0.008) and it was highly significant in cases). Both FBS and PPBS levels were higher in patient with hypomgnesemia as compared to that of patients having normal magnesium level and was statistically significant.
Conclusions: This study showed that hypomagnesaemia is common in Type 2 diabetes mellitus patients when compared to non diabetic controls. This study clearly depicts that in diabetes mellitus serum magnesium levels had a positive correlation with glycemic control.
Keywords: Type 2 diabetes mellitus, Hypomagnesaemia, Fasting blood sugar, Post prandial blood sugar, Creatinine, Glycosylated hemoglobin (HbA1c), Magnesium,.
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