Abstract
The prevalence of diabetes mellitus is on a rising trend. Though great attention has been centered on the chronic complications like retinopathy, nephropathy, neuropathy and the macrovascular complications, the pulmonary complications have been poorly characterised. The aim of the present study was to assess the effects of chronic hyperglycemia on lung function, focusing on mechanical aspects of lung dysfunction with the help of spirometry. These complications might have a significant impact on the quality of life of the patients. This study showed reduced lung function in patients with diabetes, showing a restrictive pattern of lung involvement. Diabetes duration seems a more important influence than the glycaemic control.
Keywords: Diabetes Mellitus, Spirometry.
References
- Longo, Fauci, Kasper, Hauser, Jameson, Loscalzo Harrison’s principles of internal medicine 19th
- Sandler Malcom – Is the lung a target organ in diabetes mellitus? Arch Internal Medicine 1990; 150:1385-88.
- Trinder, P. Deter mination of glucase in blood using grocase oxidose with an alternative oxygen acceptor. Ann Clin Biochem. 1969;6:24-27.
- Nathan DM. A1c-Derived Average Glucose Study Group. Translating the A1c assay into estimated average glucose values. Diabetes Care. 2008;31(8):1473–78.[PMID: 18540046].
- Davis WA, Knuiman M, Kendall P, Grange V, Davis TM. Glycemic exposure is associated with reduced pulmonary function in type 2 diabetes, the fremantle diabetes study. Diabetes Care. 2004;27:752–7. [PubMed]
- Asanuma Y, Fujiya S, Ide H, Agishi Y. Characteristics of pulmonary function in patients with diabetes mellitus. Diabetes Res Clin Pract. 1985;1:95–101. [PubMed]
- Lange P, Groth S, Kastrup J, Mortensen J, Appleyard M, Nyboe J, et al. Diabetes mellitus, plasma glucose and lung function in a cross sectional population study. Eur Respir J. 1989;2:14–9. [PubMed]
- Barrett-Conor E, Frette C. NIDDM, impaired glucose tolerance, and pulmonary function in older adults. Diabetes Care. 1996; 19: 1441-4. [PubMed]
- Davis TM, Knuiman M, Kendall P, Vu H, Davis WA. Reduced pulmonary function and its association in type 2 diabetes: The fremantle diabetes study. Diabetes Res Clin Pract. 2000; 50:153–9. [PubMed]
- Reduced pulmonary function and its associations in type 2 diabetes: the Fremantle Diabetes Study Timothy M.EDavisa Matthew Knuimanb PeterKendallc HienVub Wendy ADavisa Diabetes Research and Clinical Practice, volume 50,issue 2,October 2000
- Uchida K, Takahashi K, Aoki R, Ashitaka T. Ventilation-perfusion scintigram in diabetics. Ann Nucl Med. 1991;5:97–102. [PubMed]
- Ehrlich SF, Quesenberry CP, Vanden Eeden SK, Shan J, Ferrara A. Patients diagnosed with diabetes are at increased risk for asthma, COPD, pulmonary fibrosis and pneumonia but not lung cancer. Diabetes Care. 2010; 33:55–60. [PMC free article] [PubMed]
- Arnalich F, Hernanz A, Lopez-Maderuelo D. Enhanced acute-phase response and oxidative stress in older adults with type II diabetes. Horm Metab Res 2000;32:407–12.
- Walter R, Beiser A, Givelber R. The association between glycemic state and lung function: the Framingham heart study. Am J Respir Crit Care Med 2003;167:911–6.
- Cirillo D, Agrawal Y, Cassano P. Lipids and pulmonary function in the third national health and nutrition examination survey. Am J Epidemiol 2002;155:842–8.
- Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001; 414: 813–20.
Corresponding Author
Dr Tanzeem.S
Post Graduate, Department of General Medicine,
Rajah Muthiah Medical College and Hospital,
Annamalai University, Annamalai Nagar – 608002