Abstract
The role of serum uric acid (SUA) levels as an independent risk factor for vascular disease has been questioned for decades. Recent studies suggest that the elevated SUA levels may predict an increased risk for cerebrovascular (CV) events including stroke. If the levels of other antioxidants like ascorbic acid are low, SUA can work as pro-oxidant. Various studies showed that elevated SUA levels can result in endothelial dysfunction which can lead to vascular disease. An association between SUA and inflammatory markers has also been discovered.
Keywords: SUA, Ischemic stroke.
References
- Adam and Victor’s principles of Neurology – 10th edition; Chapter 34; page 778-792
- Squadrito GL, Cueto R, Splenser AE, Valavanidis A, Zhang H, Uppu RM, et al. Reaction of uric acid with peroxynitrite and implications for the mechanism of neuroprotection by uric acid. Arch Biochem Biophys 2000; 376: 333– 337.
- Nieto FJ, Iribarren C, Gross MD, Comstock GW, Cutler RG. Uric acid and serum antioxidant capacity: a reaction to atherosclerosis? Atherosclerosis 2000; 148:131–139.
- Adauff GW, Atkins E, Malawista SE. The fever of gout; urate crystals activate endogenous pyrogen production from human and rabbit mononuclear phagocytes. Trans Assoc Am Physician. 1983: 96: 234-245.
- Kondo N, Nomura M, Nakaya Y, Itos S, Phfuro T. Association of inflammatory marker and highly sensitive CRP with aerobic exercise capacity, maximum oxygen uptake and insulin resistance in healthy middle aged volunteers; Circ J;2005; 69(4); 452-457.
- Iribarren C, Folsom AR, Eckfeldt JH, MC Govern PG, Nieho FJ. Correlates of uric acid and its association with asymptomatic carotid atherosclerosis; the ARIC study; Atheroscle-rosis Risk in communities. Stroke, 1999; 29: 635-639.
- Hozawa, A. Folson AR. Uric acid is an independent predictor of ischemic stroke among subjects not using diuretics. Atherosclerosis, 2006, 187(2): 401-407.
- Longo Mbenza B, Luila EL, Mbete P, Vita EK. Is hyperuricemia a risk factor of stroke and coronary heart disease among Africans. Int. J. Cardiol., 1999, 71(1): 17-22.
- Chamorro A, Obach V, Cervera A, Revilla M, Deulofeu R, Aponte JH. Prognostic significance of uric acid serum concentration in patients with acute ischemic stroke. Stroke 2002; 33: 1048– 1052.
- Milionis HJ, Kalantzi KJ, Goudevenos JA, Seferiadis K, Mikhailidis DP, Elisaf MS. Serum uric acid levels and risk for acute ischemic non-embolic stroke in elderly subjects. J Intern Med 2005; 258: 435 – 441.
Corresponding Author
Dr Sheik Mohammed Raja. E.
Post Graduate, Department of General Medicine,
Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalai Nagar – 608002