Abstract
Introduction: H.pylori (HP) infection is a major cause of gastro-duodenal disease burden worldwide, causing benign as well as malignant lesions. Various methods are available for diagnosis of gastric H. pylori (gHP) infection. Presence of oral HP infection is a well documented phenomenon. Rapid urease test is being used as a quick and reliable test for detection of gHP.
Aim: We endeavor to find out whether detection of oral H. pylori (oHP) infection, using a cheap but reliable, non-invasive test like rapid urease slide test (RUT) in patients undergoing upper GI endoscopy (UGIE) for dyspepsia, predict the occurrence of gHP.
Materials and Method: We serially evaluated 250 patients undergoing routine upper GI endoscopy (UGIE) for dyspepsia over a period of 1 year, for presence of gastric and oral H. pylori. Patients with red flags and significant co-morbidities were excluded.
Results: Overall prevalence for gHP was 78.8% (197 out of 250 patients while the overall prevalence of oHP was 63.6 % (159 out of 250 patients). Patients with duodenitis and duodenal ulcer had the highest occurrence of gastric and oral H.pylori infection. Oral RUT was positive in 72.97% cases of duodenitis and 78.04% cases of duodenal ulcer.
Conclusion: Oral swab detection of Helicobacter pylori using RUT is helpful to detect the occurrence of gastric H. pylori in those patients with gastro-duodenal lesions, especially duodenitis and duodenal ulcers. This may, in the long run, be helpful to reduce the disease burden of H. pylori related diseases.
Keywords: Helicobacter pylori, dyspepsia, rapid urease test, oral plaque, upper GI endoscopy.
References
- Schwartz C. Uber penetrierende magen und jejunal geschwüre. Beitr Klin Chir. 1910;67:96–128.
- Marshall BJ, Armstrong JA, McGechie DB, Glancy RJ. Attempt to fulfil Koch’s postulates for pyloric Campylobacter. Med J Aust. 1985 Apr 15;142(8):436–9.
- Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet Lond Engl. 1984 Jun 16;1(8390):1311–5.
- Taj Y, Essa F, Kazmi SU, Abdullah E. Sensitivity and specificity of various diagnostic tests in the detection of Helicobacter pylori. J Coll Physicians Surg--Pak JCPSP. 2003 Feb;13(2):90–3.
- Song Q, Lange T, Spahr A, Adler G, Bode G. Characteristic distribution pattern of Helicobacter pylori in dental plaque and saliva detected with nested PCR. J Med Microbiol. 2000 Apr;49(4):349–53.
- Jaworski W. Podręcznik chorób żołądka (Handbook of Gastric Diseases). Wydawnictwa Dzie Lekarskich Polskich; 1899. 30-47 p.
- Warren JR, Marshall B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet Lond Engl. 1983 04;1(8336):1273–5.
- Whalen MB, Massidda O. Helicobacter pylori: enemy, commensal or, sometimes, friend? J Infect Dev Ctries. 2015 Jul 4;9(6):674–8.
- Louw JA, Jaskiewicz K, Girdwood AH, Zak J, Trey G, Lucke W, et al. Helicobacter pylori prevalence in non-ulcer dyspepsia--ethnic and socio-economic differences. South Afr Med J Suid-Afr Tydskr Vir Geneeskd. 1993 Mar;83(3):169–71.
- Khan AR. An age- and gender-specific analysis of H. Pylori infection. Ann Saudi Med. 1998 Feb;18(1):6–8.
- Jais M, Barua S. Seroprevalence of anti Helicobacter pylori IgG/IgA in asymptomatic population from Delhi. J Commun Dis. 2004 Jun;36(2):132–5.
- Gill HH, Desai HG, Majmudar P, Mehta PR, Prabhu SR. Epidemiology of Helicobacter pylori: the Indian scenario. Indian J Gastroenterol Off J Indian Soc Gastroenterol. 1993 Jan;12(1):9–11.
- De Martel C, Parsonnet J. Helicobacter pylori infection and gender: a meta-analysis of population-based prevalence surveys. Dig Dis Sci. 2006 Dec;51(12):2292–301.
- Perri F, Festa V, Grossi E, Garbagna N, Leandro G, Andriulli A, “NUD-LOOK” Study Group. Dyspepsia and Helicobacter pylori infection: a prospective multicentre observational study. Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver. 2003 Mar;35(3):157–64.
- Karczewska E, Konturek JE, Konturek PC, Cześnikiewicz M, Sito E, Bielański W, et al. Oral cavity as a potential source of gastric reinfection by Helicobacter pylori. Dig Dis Sci. 2002 May;47(5):978–86.
- Liu Y, Yue H, Li A, Wang J, Jiang B, Zhang Y, et al. An epidemiologic study on the correlation between oral Helicobacter pylori and gastric H. pylori. Curr Microbiol. 2009 May;58(5):449–53.
- De Sousa L, Vásquez L, Velasco J, Parlapiano D. [Isolation of Helicobacter pylori in gastric mucosa, dental plaque and saliva in a population from the Venezuelan Andes]. Invest Clin. 2006 Jun;47(2):109–16.
- Singh V, Trikha B, Nain CK, Singh K, Vaiphei K. Epidemiology of Helicobacter pylori and peptic ulcer in India. J Gastroenterol Hepatol. 2002 Jun;17(6): 659–65.
Corresponding Author
Dr Amol Rajendra Samarth, M.D., D.M.
Address: 99, Old Subhedar layout extn., Manewada road, Nagpur -440009
Telephone: 091-9373103428, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
DOI: https://dx.doi.org/10.18535/jmscr/v5i9.126
