Abstract
Introduction: Intra operative cytology and frozen section in carcinoma breast
Materials and Method: FNAC proven surgical specimens of breast malignancies form the Department of surgery during the period 3years. Total of 200 cases with relevant clinical details, gross morphological features of the lesions were observed and recorded. Then specimens for cytological examination and frozen section study were collected, from the suspected focus of malignancy such as infiltrative and irregular gray white areas. Nuclear grading was done on cytological smears. Cytology smears compared with frozen sections. Study was approved by the institutional ethical committee.
Result: Gross examination and intra operative cytology together gave an accuracy rate of 100% in malignant breast lesions. With frozen section alone, the accuracy rate was 96%.
Conclusion: Intra operative cytology adds confidence to frozen section study. Intra Operative consultation by cytological examination was an easy procedure to perform and requires less time compared to frozen section and is of great value in areas where frozen section facility not available.
Keywords: Intra operative cytology, frozen section, breast malignancy.
References
- Th. Schricker and P. Hermanek. Intra operative Histology or Cytology? Virchows Arch. A Path. Anat Histol. 1974; 362: 247 – 258.
- Juan Lechago. The Frozen Section: Patholpogy in the Trenches. Archives of pathology and Laboratory Medicine. 2005; 129 (12): 1529 – 1531.
- Esteban JM, Zaloudek C, Silverberg SG. Intra operative diagnosis of breast lesions. Comparison of cytologic with frozen section technics. Am.J. clin pahol. 1987; 88 (6): 681 – 688.
- Takuya Moriya, Toshiaki manabe, chotasta Tsukayma, Koshi Jamashita, Satoshi Ippon sugi, Hiroshi sonoo, and T suneaki Senoo. Imprint Immuno cyto chemisty of Estrogen Receptors in Breast carcinoma. Japanese Journal of clinical oncology 1990; 20: 159-163.
- Scope CD, Melachrinou M, A persou D, Bonikos D. Tissue imprint in surgical pathology: a rapid intra operative diagnostic aid Diagn cytopathol. 1990; 6(1): 5-8.
- Brifford M, Carbaret V, Trassard M, Labbes. Intraoperative Cytology of breast lesions. Clin Exp Pthol. 1999; 47 (6): 279 – 285.
- Suzanne E. Carlos T. Usefulness of Touch Preparation Cytology in post mortem Diagnosis. A study from the University Hospital of the West Indies. The Internet Journal of Pathology 2005; 3(2): 2-8.
- Modern Cytopathology. Kim R. Geisinger, Michael W. Stanley Jan. F. Silverman, Stephan Andvex.
- E. Pinder, 10 Ellis, CW. Elson. Prognostic factors in primary breast carcinoma. I. Clin Pathol. 1995; 48: 981 – 983.
- Hagedorn K, Kramers, Mitze M, Breuel C, Schulz – Wendtland R, Bantz W, Lang N. Inter ventional methods in breast diagnosis. Histological VS. Cytological evaluation of core cut biopsies of the breast. Aktulle Radial. 1998; 8 (6): 278 – 282.
- Szczepanik E. Intraoperative cytology of tumors Diagn cytopathol. 1986; 2(3): 236-240.
Corresponding Author
Dr Jisha K T
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DOI: https://dx.doi.org/10.18535/jmscr/v5i9.87
