Abstract
Labor, an important event, is marked by the fear of pain. Painless and short labor is desired. Obstetricians goal is, healthy neonate and mother. Methods used to shorten active phase of labor are welcomed. Prolonged labor causes high feto-maternal morbidity. Shortening of duration of labor, without jeopardizing feto- maternal interests is warranted,. Various methods tried to accelerate labor. Hyoscine-n-butyl bromide, scopolamine and Valethamate bromide widely studied. Present study conducted to compare effects of Drotavarine hydrochloride and combination of Hyoscine-N-butyl bromide plus Valethamate bromide on duration of active phase and their feto-materal side effects. 200 women divided into two groups 100 each. Group A received Drotavarine hydrochloride 40mg I/M, 2 doses 2 hours apart(2nd if required). Group B given combination of Hyoscine-N-butyl bromide 40 mg and Valethamate bromide 16mg I/M, 2 doses 2 hours apart(2nd if required). 98% delivered vaginally. 2% (LSCS) in each group and excluded. Mean no. of doses 1.36±0.48 (Group A), 1.83±0.37 (Group B) p value <0.001 HS. Mean rate of dilatation (cms/hr) was more in Group A(3.81±1.52) than B (2.29±0.64) p value<0.001 HS. Mean Active phase was 112.70±53.09 mins in Group A and 171.44±57.24 min in B, p value<0.001 HS. Drug-delivery interval was 45.10±63.22 min (groupA) and 202.09±60.35 min (Group B) p value <0.001HS. No serious feto-maternal side effects. Drotavarine and combination drugs are safe to shorten the duration of active phase.
Keywords: Drotavarine,Valethamate, active phase. Dilatation.
References
- Shahul R, Chapman A. Role of drugs in acceleration of normal labor. J Obstet Gynecol Ind 1984; 34:501-504.
- Philpot RH, Castle WM. Cervicographs in the management of labor in primigravida; the alert line for detecting abnormal labor. J Obstet Gynecol Brit C’wlth 1972; 79:592.
- World Health Organization. Managing Prolonged and Obstructed Labor. Education material for teachers of midwifery: midwifery education modules. – 2nd ed,2008:54-64
- Mitchell MD, Flint, APF, Bibby J et al. Rapid increase in plasma PG concentration after vaginal examination and amniotomy. Br Med J 1997; 2:1183-84.
- Busowskie JD, Passons NJ. Amniotomy to induce labor. Clin Obstet Gynecol 1995; 38(2):256-49.
- Fraser WD, Sauve R, Singh PW et al. A randomized controlled trial of early anatomy. Br J Obstet Gynecol 1991; 98(1):84-91.
- Shykin JM, Petrie RH. Oxytocin to induce labor. Clin Obstet Gynecol 1995; 38(2):202-12.
- Cheng YW, Shaffer BL, Bryant AS, Caughey AB. Length of the first stage of labor and associated prenatal outcomes in nulliparous women. Obstet and Gynecol 2010; 116:1127-35.
- Vellanki VS. Comparison of buscopan and epidosin on cervical dilatation in labour. Global journal of medical research 2010;10(2): 18-21.
- Sharma JB, Pundir P, Kumar A, Murthy NS. Drotavarine hydrochloride v/s Valethamate bromide in acceleration of labour. Int J Gynae Obst 2001 Sep; 74(3):255-60.
- Nagaria T, Jaiswal J. To compare and evaluate the efficacy and safety of Drotavarine and Valethamate bromide. J Obst Gynae India 2009; 59(4):324-33.
- Madhu C, Mahavarkar S, Bhave S. A randomized controlled study comparing Drotavarine hydrochloride and Valetha-mate bromide in the augmentation of labor. Arch Gynecol Obstet.2010;282 (1):11-5
- Naga P, Shivanna BS, Subbappa K, Gopal N. Comparative Study of Efficacy of Combination of Valethamate Bromide & Buscopan with Drotavarine Hydrochloride on Cervical Dilatation in Active Labor. IOSR-JDMS 2014 Oct; 13(10):27-29.
- Kaur S, Bajwa SK, Kaur P, Bhupal S. To Compare the Effect of Camylofin Dihydrochloride (Anafortan) with Combination of Valethamate Bromide (Epidosin) and Hyoscine Butyl-N-Bromide (Buscopan) on Cervical Dilation. J Clin Diagn Res. 2013 Sep; 7(9): 1897–1899.
- Edessy M et al. Different modalities in first stage enhancement of labor. Gen. Health Med Sci.,2015;(2):1-4
- Patil AB, Kalhon P, Patel R. Comparative study of Drotavarine Hydrochloride and Valethamate Bromide in progress of labor. International Journal of Recent Trends in Science and Technology, 2015;14(3):678-682
- Dahal P et al. Health Renaissance Efficacy of Drotavarine hydrochloride & Valethamate bromide in labor. 2013; 11(1); 38-42.
- Selvaraj SM, Natarajan S. Comparison of Drotavarine hydrochloride and Valetha-mate bromide on cervical dilatation. Journal of Evolution of Medical and Dental Sciences, 2016;5(52):3391-3394
- Kalhon P ,Patil AB, Patel R. Efficavy of intramuscular Drotavarine use for cervical dilatation in first stage of labor. International Journal of Recent Trends in Science and Technology, 2015;14(3): 670-674.
- Jayashree S, Ajjammanavar V, Sujatha MS. Int J Biol Med Res 2013; 4(2):3215-3218
Corresponding Author
Balwinder Kaur
Associate Professor
360 North Avenue, Bhadson Road Patiala Punjab India, 147001
Email: This email address is being protected from spambots. You need JavaScript enabled to view it., +919814486292
DOI: https://dx.doi.org/10.18535/jmscr/v5i9.74
