Abstract
Introduction
Febrile seizures [FS] are the most common seizures in children. Their incidence is ranged between 2-5 %.(1) Febrile seizure is more common in boys, usually manifesting as tonic-clonic convulsion.(2) Although FS is benign and rarely leads to brain damage, it causes emotional, physi-cal, and mental damages, which are stressful for parents, and affects families’ quality of life (3,4). Many studies have tried to find its risk factors, because of its relation to epilepsy in 2-4% in future, the fact that it can lead to hospitalization, costs for families and the society, and likelihood of recurrence (30% and 50% after the first and the second occurrences, respectively) (3, 5).
References
- Berg AT. Febrile seizures and epilepsy: the contribution of epidemiology. Paediatric and Perinatal Epidemiology 1992;6:145–52.
- Humite Haddad A, About-Khalid B. Epilepsy diagnosis and localization in patients with antecedent childhood febrile convulsions.Neurology,1998;50(4):917-22
- Jones T, Jacobsen SJ. Childhood Febrile Seizures:Overview and Implications. Int J Med Sci. 2007; 4(2):110-4.
- Flury T, Aebi C, Donati F. Febrile Seizures and Parental Anxiety: Does Information Help? Swiss Med Wkly 2001; 131:556–60.
- Kliegman RM, Stanton BF, St Geme JW, Schor NF, Behrman RE. Nelson Textbook of Pediatrics. 19th Philadelphia (PA): WB Saunders Company; 2011.p.2017.
- DeUngria M, Rao R, Wobken JD, Luciana M, Nelson CA, Georgieff MK. Perinatal iron deficiency decreases cytochrome c oxidase (CytOx) activity in selected regions of neonatal rat brain. Pediatric Research 2000;48:169–76.
- Parks YA and Wharton BA. Iron deficiency and the brain. Acta Paediatr Scand. 1989; 55(suppl 361): 71– 77.
- Pisacane A, Sansone R, Impagliazzo N, Coppola A, Rolando P, D’ Apuzzo A. Iron deficiency anemia and febrile convulsions: Case – control study in children under 2 years. BMJ 1996;313:43.
- Abaskhanian A, Vahid K, Parvinnejad N. The association between iron deficiency and the first episode of febrile seizures, J Babol Univ Med Sci 2009;11(3):32-36.
- Pisacane A, Sansone R, Impagliazzo N, Coppola A, Rolando P, D’Apuzzo A, et al. Iron Deficiency Anemia and Febrile Con-vulsions: Case-control Study in Children under 2 Years. BMJ 1996;313 (7053):343.
- Ur-Rehman N, Billoo AG. Association between Iron Deficiency Anemia and Febrile Seizures. J Coll Physicians Surg Pak 2005;15(6):338-40.
- Daoud AS, Batieha A, Abu-Ekteish F, Gharaibeh N, Ajlouni S, Hijazi S. Iron Status: A Possible Risk Factor for the First Febrile Seizure. Epilepsia 2002;43(7):740-3.
- Hartfield DS, Tan J, Yager JY, Rosychuk RJ, Spady D,Haines C, et al. The Association between Iron Deficiency and Febrile Seizures in Childhood. Clin Pediatr (Phila) 2009;48(4):420-6.
- Talebian A, Momtazmanesh N. Febrile Seizures and Anemia. Iran J Child Neurol 2007; 2(1):31-3.
- Kobrinsky NL, Yager JY, Cheang MS, Yatscoff RW, Tenenbein M. Does Iron Deficiency Raise the Seizure Threshold? J Child Neurol 1995;10(2):105–9.
- Salehi Omran MR, Tamaddoni A, Nasehi MM, Babazadeh H, Alizadeh Navaei R. Iron Status in Febrile Seizure: A Case-control Study. Iran J Child Neurol 2009:3(3):40-3.
- Amirsalari S, Keihanidost Z, Ahmadi M, Sabouri A, Kavemanesh Z, Afshar P, et al. Relationship between Iron Deficiency Anemia and Febrile Seizures. Iran J Child Neurol 2010;14(1):27-30.
- Hartfield, D. S., Tan, J., Yager, J. Y., Rosychuk, R. J., Spady, D., Haines, C., & Craig, W. R. (2009). The Association between Iron Deficiency and Febrile Seizures in Childhood. Clin Pediatr (Phila), 48(4), 420-6.
- Kobrinsky, N. L., Yager, J. Y., Cheang, M. S., & Yatscoff, R. W. (1995). Tenenbein M. Does Iron Deficiency Raise the Seizure Threshold? J Child Neurol, 10(2), 105-9. http://dx.doi.org/10.1177/088307389501000207
- Bidabadi, E., & Mashouf, M. (2009). Association between Iron Deficiency Anemia and First Febrile Convulsion:A Case-control Study. Seizure, 18, 347-351. http://dx.doi.org/10.1016/j.seizure.2009.01.008
- Momen AA, Hakimzadeh M. Case–control study of the relationship between anemia and febrile convulsion in children between 9 months and 5 years of age. Scientific Medical Journal of Ahwaz University of Medical Sciences 2003;1(4):50–4.
- Sadeghzadeh M, Khoshnevis P, Mahboubi E. Iron Status and Febrile Seizure- A Case Control Study in Children Less Than 3 Years. Iran J Child Neurol 2012;6(4):27-31.
- Naveed-Ur-Rehman. Billo AG. Associa-tion between iron deficiency anemia and febrile seizures. Journal of College of Physicians and Surgeons Pakistan 2005; 15(6):338–40.
- Pisacane A, Sansone R, Impagliazzo N, Coppola A, Rolando P, D’Apuzzo A, et al. Iron deficiency anemia and febrile convulsions: case–control study in children under 2 years. British Medical Journal 1996;313:343.
- Vaswani RK, Dharaskar PG, Kulkarni S, Ghosh K. Iron Deficiency as a Risk Factor for First Febrile Seizure. Indian Pediatr 2009;47(5):437-9.
- Ur-Rehman N, Billoo AG. Association between Iron Deficiency Anemia and Febrile Seizures. J Coll Physicians Surg Pak 2005;15(6):338-40.
Corresponding Author
Patel N
Department of Pediatrics,
Sri Aurobindo Institute Medical Sciences, Indore 453111
DOI: https://dx.doi.org/10.18535/jmscr/v5i9.20
