Title: Comparision of Etomidate versus Propofol for Anaesthesia in Short Case Surgical Procedures
Authors: Dr Karan M Patel, Dr Alpa Patel, Dr Vaibhavi Hajariwala, Dr Jay Patel
DOI: https://dx.doi.org/10.18535/jmscr/v5i4.130
Abstract
Background: Etomidate and Propofolare two ultra short-acting IV induction agents. Studies for long duration surgeries found that etomidate provides effective, reliable anaesthesia, rapid recovery and minimal side effect but very less studies are available for short duration surgical procedures. A present study was aimed to evaluate hemodynamicchanges, compare duration of recovery from anaesthesia and compare safety of both drugs.
Material and Methods: We conducted single centred, open labelled, parallel group Randomised Control Trial on 60 patients between 18 to 60 years age, having physical status ASA I, II or III undergoing elective or emergency short (less than or equal to 30 minutes) surgical procedures. Patients who met inclusion criteria were randomly divided into two groups of 30 each based on computer generated software after taking written and informed consent. Patients were given premedication and IV induction agent (loading dose) followed by i.v. infusion according to their group.
Results: Mean of Modified Aldrete Score and Modified Observer's Assessment of Alertness Score were 9.06 & 9.87, 4.25 &4.9; Group P and E respectively. Mean variation of HR and MAP after 5 mins of induction was less significant. But SPO2 was 2.57 and 0.17, in group P & E respectively (P value=0.026). Recovery duration from anaesthesia was much rapid and faster in Group E. Fewer side effects were observed in group E.
Conclusions: Etomidate was haemo dynamically more stable and showed rapid recovery and lesser side-effects in comparision to propofol. But both were equally efficacious.
Keywords: Propofol, Etomidate, TIVA.
