Abstract
Introduction: Coronary heart disease is common cause of morbidity and mortality worldwide. Vitamin D deficiency is common in general population, and is more prevalent among hospitalized patients.
Vitamin D regulate cardiac contraction through its receptors in cardiac myocyte, and many studies support its role in acute myocardial infarction and heart failure. In this study, we seek to investigate the existence of an association between vitamin D and coronary heart disease in hospitalized patients.
Material and Method: A case control study with 120 cases of coronary artery disease and 40 healthy controls was conducted. The standard clinical and biochemical risk factor for myocardial infarction were assessed in both cases and controls. Serum vitamin D assay was performed in cases and controls using radioimmunoassay technique.
Observation: Vitamin D deficiency < 20 ng/ml was higher in cases (67%) than control (50%), with respect to this mean level was lower in case (18.96 ng/ml) and control ( 21.84 ng/ml) respectively. P value is < 0.0394.
Conclusion: This study reveals high prevalence of vitamin D Deficiency in case and controls with level of 25 (OH) D being significantly lower among cases.
References
1. Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006;
2. Malabanan A, Veronikis IE, Holick MF. Redefining vitamin D insufficiency. Lancet. 1998; 351:
3. Chapuy MC, Preziosi P, Maamer M, Arnaud S, Galan P, Hercberg S, Meunier PJ. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int. 1997;
4. Nesby-O’Dell S, Scanlon KS, Cogswell ME, Gillespie C, Hollis BW, Looker AC, Allen C, Doughertly C, Gunter EW, Bowman BA. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988–1994. Am J Clin Nutr. 2002; 76: 187–192.
5. Kendricka J, Targherb G, Smitsa G, Chonchola M. 25-Hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey. Atherosclerosis
6. Krause R, Buhring M, Hopfenmuller W, Holick MF, Sharma AM. Ultraviolet B and blood pressure. Lancet.
7. Nibbelink KA, Tishkoff DX, Hershey SD, Rahman A, Simpson RU. 1,25(OH)2-vitamin D3 actions on cell proliferation, size, gene expression, and receptor localization, in the HL-1 cardiac myocyte. J Steroid Biochem Mol Biol Mar. 2007;103:533–7.
8. Wu-Wong JR, Nakane M, Ma J, Ruan X, Kroeger PE. Effects of Vitamin D analogs on gene expression profiling in human coronary artery smooth muscle cells. Atherosclerosis. 2006;186:20–8.
9. Merke J, Milde P, Lewicka S, Hügel U, Klaus G, Mangelsdorf DJ, et al. Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of1,25-dihydroxyvitamin D3. Studies in cultured bovine aortic endoth-elial cells and human dermalcapillaries. J Clin Invest. 1989;83:1903–15.
10. Krause R, Buhring M, Hopfenmuller W, Holick MF, Sharma AM. Ultraviolet B and blood pressure. Lancet. 1998;352:709–10.
11. Judd S, Tangpricha V. Vitamin D deficiency and risk for cardiovascular disase. Circulation.
12. John Hle,Rajyalakshmigadi,John a spertus et al, Prevalence of vitamin Ddeficiency in acute myocardial infarction. AMJ Cardiology june 2011vol107:1636-1638
13. Karman Mahadevi,Zahra Amirajam, Saeed Yazdankhan, Shahla Majidi, Mohammad Hassan adelet,The prevalence and prognostic role of vit D deficiency in a patient with acute coronary syndrome. Heart lung circulation 2013 vol22page 346-351
14. Zahra danasiadat, Keyvan Kiani, Masoumeh Sadeghi, Vitamin D deficiency and coronary artery disease, Journal research in medical science.2012vol 17(11) 1052-1055
15. Hyder o mirgani, Osama S Mohammed, Abdull A Alysunuf,Vitamin d deficiency among patients with acute coronary syndrome and its relation to in hospital complication”. Indian journal of applied research vol 5 june2015.
16. Hyder o mirgani, Osama S Mohammed, Abdull A Alysunuf,Vitamin d deficiency among patients with acute coronary syndrome and its relation to in hospital complication”.Indian journal of applied research vol 5 june 2015.
DOI: https://dx.doi.org/10.18535/jmscr/v5i4.73
