Title: Evaluation of Left Ventricular Diastolic Dysfunction in Asymptomatic Normotensive Patients with Type-2 Diabetes Mellitus
Authors: Kalyan Mansukhbhai Shekhda, Alpesh Himmatbhai Gohil, Mayank Gaur
DOI: https://dx.doi.org/10.18535/jmscr/v5i4.62
Abstract
Introduction: Diabetes mellitus (DM) is known to affect cardiovascular system adversely. Various studies reported left ventricular diastolic dysfunction (LVDD) as an early sign of cardiac involvement in asymptomatic patients with type-2 DM, diagnosed using Color Doppler echocardiography. With this background, the study was conducted with an aim to study the prevalence of LVDD in normotensive asymptomatic type-2 DM patients and association with various risk factors.
Methodology: The cross-sectional study was carried out among the type 2 DM patients who visited our hospital for regular follow-up. 100 patients of type 2 DM were enrolled and patients without the history of hypertension, Heart diseases, renal dysfunction were recruited on a convenient basis. Demographic data such as age, sex, history, duration, treatment of DM, Investigations like Fasting and Postprandial blood sugar levels, Serum Creatinine, Fasting lipid profile, HbA1c, and also ECG, 2D echocardiography, and Treadmill test were carried out. Data were entered in MS Excel spread sheet and analysed with the help of SPSS software packages and Open Epi. Chi-square test was used for the comparison of qualitative data.
Results: LVDD was present in 64 (64%) among 100 patients. A strong association of LVDD with Duration of Diabetes and HbA1c (p<0.001) was observed but there was no correlation with age, sex, Type of Treatment, total cholesterol, triglycerides, high-density lipoprotein.
Conclusion: Duration of diabetes and the level of HbA1c were found to have a strong association with LVDD. It is recommended that all patients with long term and uncontrolled type 2 DM should be screened for LVDD.
Keywords: LVDD, Duration of diabetes, HbA1c, Total cholesterol, Triglycerides, Diabetic cardiomyopathy.
