Title: Histopathological Study of Colorectal Carcinomas
Authors: Dr K Shilpa, Dr Monica G S
DOI: https://dx.doi.org/10.18535/jmscr/v5i4.13
Abstract
Introduction: Colorectal carcinoma ranks the fourth most frequent cancers in men and third in women which causes significant mortality and morbidity. Studies have shown increasing trend in incidence in India. Chronic inflammatory bowel diseases like ulcerative colitis, crohn’s disease and schistosoma mansoni infection, high calorie diet and sedentary life style are etiological factors for colorectal carcinoma. Pathological examination of the biopsy and resected specimens is important for appropriate patient management, prognosis assessment and family counselling.
Aims and Objectives: This is a retrospectively conducted study at our institute to evaluate histopatholo-gically the colorectal carcinomas based on age and sex distribution.
Material and Methods: All cases of abdominoperineal resection, colectomy, rectal and colonic biopsy received in the Department of Pathology, Mysore Medical College and Research Institute over a period of 3 years (between july 2013 – july 2016) were evaluated.
Results: The study included 75 cases with almost equal prevalence in males and females, with most of the cases occurring in 6th decade and adenocarcinoma not otherwise specified is the most common malignancy and rectum being the commonest site.
Conclusion: Colorectal adenocarcinoma is a heterogenous disease that involves multiple tumorigenic pathways. Prediction of prognosis in colorectal cancer is vital for the choice of therapeutic options. Histopathologic diagnosis remain paramount importance in this aspect.
Keywords: Adenocarcinoma, Rectum, Tumor grade.
