Abstract

This was a comparative study, spanning over a period of two years on 100 selected hypertensive patients who satisfied certain inclusion and exclusion criteria. The study was carried out in Indira Gandhi institute of cardiology, Patna. Bihar to compare the adverse effect of combination antihypertensive agents i.e. Amlodipine (5mg) with Lisinopril (10mg) and Amlodipine (5mg) with Losartan (50mg). All the patients were followed up regularly at an interval of one month for clinical history, and compliance, and relevant physical examination and biochemical parameters. After treatment for two years it was observed that Amlodipine with Losartan combination is better than Amlodipine with Lisinopril combination because the former group reported lesser adverse effects like cough , ankle edema and better control of blood pressure

Keywords: Hypertension, Amlodipine, Losartan, Lisinopril.