Abstract
Objective: To study the Ulcer Index, gross morphology and histopathological pictures of effect of Ethanol extract of curcuma longa (CLE) on Aspirin induced gastric injuries.
Method: After animal ethics committee approval, the effect of CLE was studied on ten groups of guinea pigs.
Group I & 2 were given 1% carboxy methyl cellulose (CMC) & Aspirin 500 mg/kg in 1% CMC respectively. Group 3, 4,5,&,6 were given CLE 20,40, 80 &160mg/kg respectively in 1% CMC followed one hour after by Aspirin. Group 7,8 &9 were given CLE 20, 40 & 80mg/kg respectively. Group-10 received Ranitin 30mg/kg followed one hour after by Aspirin. Ulcer-Index was calculated and analysed statistically and the histopathology study of gastric mucosa was undertaken.
Results: CLE up to 80mg/kg did not produce any gastric injury. Pretreatment with CLE 80mg/kg & 160mg/kg produced highly significant protection [P<0.001] against Aspirin induced gastric injuries & hemorrhages.
Conclusion: Ethanol extract of curcuma longa prevents Aspirin Induced gastric injury.
Keywords: Gastric ulcer, Curcuma-longa, Anti-inflammatory, Histopathology.
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DOI: https://dx.doi.org/10.18535/jmscr/v5i3.213
