Title: Study for Comparison of Iron Sucrose & Iron Sorbitol Citrate in Fixed Doses in Iron Deficiency Anemia during Pregnancy in a Tertiary Care Center
Authors: Dr Dev N. Shukla, Dr Badri Lal Patidar Dr Mamta Sharma, Dr Shivraj Meena
DOI: https://dx.doi.org/10.18535/jmscr/v5i3.147
Abstract
Background: Anemia is one of the most commonly encountered medical disorders in pregnancy & Iron deficiency is the leading cause of anemia in pregnancy. Aim of the study was to assess the efficacy of Iron Sucrose and Iron Sorbitol Citric Acid & to assess the safety and tolerability of these drugs in pregnant women with moderate anemia.
Methods: In this study, 100 antenatal cases of gestational age 14-32 weeks with hemoglobin 7-9 gm/dl were randomly divided into two groups of 50 each, which received a fixed dose of IV Iron Sucrose (Group A) & IM Iron Sorbitol Citric Acid therapy (Group B). The efficacy of the therapy was assessed by laboratory parameters such as hemoglobin, hematocrit, MCV, MCH, MCHC and serum ferritin level after 14 and 28 days. To assess the safety, adverse drug reactions with both the therapies were recorded.
Results: Pretreatment hemoglobin was 7.6±0.35 gm/dl & 7.6±0.31 gm/dl in Group A & B respectively. Hemoglobin concentration increased significantly (P<0.001), increase in Hb after 4 weeks of starting therapy was 1.2 gm/dl & 0.5 gm/dl in Group A & Group B respectively. Rise in other parameters (MCV, Ferritin etc) although were minimal but more in IV Group & statistically significant (p<0.05). Adverse events were more common with Iron Sorbitol Citric Acid therapy.
Conclusion: Intravenous therapy appears to be safer, faster, effective & more convenient than Intramuscular therapy in treatment of Iron deficiency anemia during pregnancy.
Keywords: Sorbitol, Sucrose, ferritin, Anemia, Pregnancy.
Dr Mamta Sharma
Professor, Department of Department of Obstetrics & Gynecology, J K Lon Hospital,
Govt Medical College Kota Rajasthan India
Address – Type III/10, Medical College Campus
Govt Medical College Kota Rajasthan Pin Code 324005
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