Title: Systemic Lupus Erythematosis and Adverse Pregnancy out Come - A Prospective Study
Authors: C. Jayakumari, Nirmala.C, Shahida J, Sujatha Y
DOI: https://dx.doi.org/10.18535/jmscr/v5i3.140
Abstract
Background: Systemic lupus erythematosus (SLE) is one of the most common autoimmune disorders that affect women during their childbearing years. It is an idiopathic chronic inflammatory disease that affects skin, joints, kidneys, lungs, serous membrane, nervous system, liver and other organs of the body. SLE increases the risk of spontaneous abortion, intrauterine fetal death, preeclampsia, intrauterine growth retardation, and preterm birth
Objective: The Primary objective of the study was to find out the maternal and fetal outcome of SLE complicating pregnancy and diagnosed prior to pregnancy.
Methodology: This study was conducted in the Department of Obstetrics and Gynecology in, S.A.T hospital in Govt. Medical College Trivandrum, Kerala in collaboration with the Department of Medicine. This was a prospective follow up study. 36 pregnant women were recruited based on diagnosis of SLE prior to pregnancy.
Results: SLE is associated with high proportion of maternal and fetal morbidity and mortality.. 27.8% of cases had preterm labour. There was one case of maternal mortality due to intra cerebral thrombosis. Rate of caesarean section is 56.7%, which is significantly higher than average. IUGR, Intra uterine death and low birth weight were also significantly higher.
Conclusion: We conclude that mother with SLE has a significantly higher risk of obstetric and fetal complication including mortality, in spite of the fact that they were on treatment prior to getting pregnant. Multidisciplinary, tertiary care centres equipped with Obstetric critical care unit is essential to improve outcomes.
Keywords: SLE, Pregnancy outcome, IUGR, Pre eclampsia , fetal outcomes.
Nirmala.C
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