Title: Oral Midazolam and Ketamine as Premedicants in Children- A Randomized Open Label Single Centre Study
Authors: Bhalerao Pradnya M, MD, Thombre Shalini K., MD
DOI: https://dx.doi.org/10.18535/jmscr/v5i3.106
Abstract
Operation theatre and emergency room environment induces fears in a child which include those due to separation from parents, of pain, fear of the unknown and unfamiliar environment and fear due to loss of control and privacy. Pre-medication with anxiolysis and sedation may help to tide over these issues. We thus conducted this study to evaluate the effectiveness of oral midazolam and oral ketamine as premedicants in children.100 children between the age group of 2-8years undergoing surgery lasting 1-1.5hours were considered for this study. The primary objective was to The primary objective was to compare the two in terms of haemodynamic, anxiolysis, and onset and level of sedation. The secondary objective was to look into side effects if any. We found that the two groups were comparable in terms of demographics and haemodynamics. Onset of sedation was faster with midazolam. The sedation score, anxiolysis score, separation from parents score, anxiolysis on venepuncture were similar in both the groups. The side effects, though few, were more in the ketamine group.
Keywords: Oralpremedication,midazolam,ketamine.
Dr Pradnya Bhalerao
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